Efek Ekstrak Kulit Mangga Arumanis terhadap Penurunan Edema Kaki Mencit Putih Jantan yang Diinduksi Karagenin (The Effect of Arumanis Mango Peel Extract on Decreasing the Paw Oedema in White Male Mice Induced by Carrageenin)

  • Ongky Dyah Anggraini Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Jember
  • Cicih Komariah Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Jember
  • Aris Prasetyo Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Jember

Abstract


Mango is a plant contains many active compounds with health benefits. Total phenolic content of mango peel is higher than mango flesh, with its major component are mangiferin and quercetin. Quercetin has anti-inflammatory effects through the inhibition of inflammatory mediators are serotonin, bradykinin, histamine and prostaglandin, possibly could reduce oedema as a sign of inflammation. This study used carrageenin to induce inflammation by making paw oedema in mice. The aim of this research was to know the effect of arumanis mango peel extract to reduce paw oedema in white male mice. The was quasi experimental study with 7 study groups. Spearman analyses showed a correlation with significance of (p= 0.003) that mean it has a significant correlation (p <0.01) at the 330th min. Spearman correlation coefficients was 0,632, indicated that the dose of extract and paw oedema have strong correlation. It can be concluded that mango peel extract has effect for reducing paw oedema in white male mice, with the smallest dose was 1,002mg / gBW.

 


Keywords: mango, quercetin, paw oedema


 

Published
2018-05-04
How to Cite
ANGGRAINI, Ongky Dyah; KOMARIAH, Cicih; PRASETYO, Aris. Efek Ekstrak Kulit Mangga Arumanis terhadap Penurunan Edema Kaki Mencit Putih Jantan yang Diinduksi Karagenin (The Effect of Arumanis Mango Peel Extract on Decreasing the Paw Oedema in White Male Mice Induced by Carrageenin). Pustaka Kesehatan, [S.l.], v. 6, n. 2, p. 267-271, may 2018. ISSN 2355-178X. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/7666>. Date accessed: 21 aug. 2019. doi: https://doi.org/10.19184/pk.v6i2.7666.
Section
Articles