Sintesis 1-(4-metoksibenzoiloksimetil)-5-fluorourasil sebagai Agen Antikanker

  • . Ifada Jurusan Farmasi, Fakultas Farmasi, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.
  • Ayik Rosita Puspaningtyas1 Jurusan Farmasi, Fakultas Farmasi, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.
  • Ika Oktavianawati Jurusan Kimia, Fakultas MIPA, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.
  • Yuni Retnaningtyas Jurusan Farmasi, Fakultas Farmasi, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.
  • Nia Kristiningrum Jurusan Farmasi, Fakultas Farmasi, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.

Abstract

A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5-fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4-methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid.

Keywords: 5-fluorouracil derivates, anticancer, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil, benzoylation.

How to Cite
IFADA, . et al. Sintesis 1-(4-metoksibenzoiloksimetil)-5-fluorourasil sebagai Agen Antikanker. Pustaka Kesehatan, [S.l.], v. 1, n. 1, p. 35-39, oct. 2013. ISSN 2721-3218. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/517>. Date accessed: 16 nov. 2024.
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Vol 1 No 1 (2013)
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