Optimasi Polimer Hidroksipropil Metilselulosa K-4M dan Carbopol 940 pada Sediaan Patch Dispersi Padat Meloksikam  (Optimization of Hydroxypropyl Methylcellulose K-4M and Carbopol 940 as Polymer in Solid Dispersion Meloxicam Patch)

Indarto Adikusumo; Lidya Ameliana; Dwi Nurrahmanto

Optimasi Polimer Hidroksipropil Metilselulosa K-4M dan Carbopol 940 pada Sediaan Patch Dispersi Padat Meloksikam (Optimization of Hydroxypropyl Methylcellulose K-4M and Carbopol 940 as Polymer in Solid Dispersion Meloxicam Patch)

Indarto Adikusumo Fakultas Farmasi Universitas Jember
Lidya Ameliana Fakultas Farmasi Universitas Jember
Dwi Nurrahmanto Fakultas Farmasi Universitas Jember

Abstract

Meloxicam is non steroidal antiinflammatory drug (NSAID) of the enolic acid class which is widely used in treatment of rheumatoid arthritis. Its adverse effects of oral route, which are nausea dan diarrhea could be evaded by using transdermal patch. Meloxicam is practically insoluble in water, therefore it should be made into solid dispersion.The aims of this research was to determine the effect of combination of hydroxypropyl methylcellulose (HPMC) K-4M and carbopol 940 on the in-vitro drug release and moisture content (MC) and to obtain the optimum formula of those polymers using design experts software. Meloxicam patches were prepared into three formulas based on simplex lattice design with the ratio of HPMC K-4M : carbopol 940 that were 1: 0 ; 0.5 : 0.5 and 0 : 1. The results of this research showed that the patch with HMPC K-4M : carbopol 940 of 0:1 gave the best in-vitro drug release and MC. The optimum formula was HPMC K-4M and carbopol 940 with the ratio of 0 : 1

Keywords: meloxicam, solid dispersion, patch, HPMC, carbopol.

Published

2015-09-08

How to Cite

ADIKUSUMO, Indarto; AMELIANA, Lidya; NURRAHMANTO, Dwi. Optimasi Polimer Hidroksipropil Metilselulosa K-4M dan Carbopol 940 pada Sediaan Patch Dispersi Padat Meloksikam (Optimization of Hydroxypropyl Methylcellulose K-4M and Carbopol 940 as Polymer in Solid Dispersion Meloxicam Patch). Pustaka Kesehatan, [S.l.], v. 3, n. 3, p. 436-442, sep. 2015. ISSN 2721-3218. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/3032>. Date accessed: 22 nov. 2024.

Citation Formats

Issue

Vol 3 No 3 (2015)

Section

Articles

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