Deteksi Lesi Aterosklerosis Koroner pada Model Tikus Periodontitis (Detection of Coronary Atherosclerotic Lesions in Periodontitis Rat Model)

Roza Nafilah; Rendra Chriestedy Prasetya; I Dewa Ayu Susilawati

Deteksi Lesi Aterosklerosis Koroner pada Model Tikus Periodontitis (Detection of Coronary Atherosclerotic Lesions in Periodontitis Rat Model)

Roza Nafilah Fakultas Kedoktean Gigi Universitas Jember
Rendra Chriestedy Prasetya Fakultas Kedoktean Gigi Universitas Jember
I Dewa Ayu Susilawati Fakultas Kedoktean Gigi Universitas Jember

Abstract

Background: Recent concept istated that periodontitis can induce the formation of coronary atherosclerotic lesions but there is less experimental study about that. Purpose: Analyze the effect of periodontitis on the formation of coronary atherosclerotic lesions.The parameters are coronary artery wall thickness, collagen intimal disintegration, atheroma, stenosis, endothelial disintegration, lipid deposition and fatty emboly. Methods: This experimental laboratoris (in vivo) study used male wistar rats with a total sample of 12 animals, were divided into 2 groups: control and periodontitis treatment that were prepared by mounting wire ligature and Porphyromonas gingivalis injection (0,5 McFarland/1,5x10⁸ CFU/ml) in the gingival sulcus left mandibular first molar teeth 3 times a week for 4 weeks. On 5^th week, mice were secrificed and heart that contain the coronary arteries was taken. Heart were fixed , histological preparations were made and colored by Picrosirius Red and Oil Red O. Results: The Arterial walls of periodontitis group are significantly (p <0.05) thicker than the control group. the presence of collagen intimal disintegration, atheroma, stenosis, endothelial disintegration, lipid deposition and fatty emboly are also significantly (p<0,05) more in periodontitis group than in the control group. Conclusion: Periodontitis increase the risk of coronary atherosclerotic.

Keywords: Atherosclerosis Lesion, Periodontitis

Published

2015-05-02

How to Cite

NAFILAH, Roza; PRASETYA, Rendra Chriestedy; SUSILAWATI, I Dewa Ayu. Deteksi Lesi Aterosklerosis Koroner pada Model Tikus Periodontitis (Detection of Coronary Atherosclerotic Lesions in Periodontitis Rat Model). Pustaka Kesehatan, [S.l.], v. 3, n. 2, p. 217-223, may 2015. ISSN 2721-3218. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/2531>. Date accessed: 05 nov. 2024.

Citation Formats

Issue

Vol 3 No 2 (2015)

Section

Articles

e-Journal Pustaka Kesehatan has CC-BY-SA or an equivalent license as the optimal license for the publication, distribution, use, and reuse of scholarly work. Authors who publish with this journal retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.