Deteksi Lesi Aterosklerosis Koroner pada Model Tikus Periodontitis (Detection of Coronary Atherosclerotic Lesions in Periodontitis Rat Model)

  • Roza Nafilah Fakultas Kedoktean Gigi Universitas Jember
  • Rendra Chriestedy Prasetya Fakultas Kedoktean Gigi Universitas Jember
  • I Dewa Ayu Susilawati Fakultas Kedoktean Gigi Universitas Jember

Abstract

Background: Recent concept istated that periodontitis can induce the formation of coronary atherosclerotic lesions but there is less experimental study about that. Purpose: Analyze the effect of periodontitis on the formation of coronary atherosclerotic lesions.The parameters are coronary artery wall thickness, collagen intimal disintegration, atheroma, stenosis, endothelial disintegration, lipid deposition and fatty emboly. Methods: This experimental laboratoris (in vivo) study used male wistar rats with a total sample of 12 animals, were divided into 2 groups: control and periodontitis treatment that were prepared by mounting wire ligature and Porphyromonas gingivalis injection (0,5 McFarland/1,5x108 CFU/ml) in the gingival sulcus left mandibular first molar teeth 3 times a week for 4 weeks. On 5th week, mice were secrificed and heart that contain the coronary arteries was taken. Heart were fixed , histological preparations were made and colored by Picrosirius Red and Oil Red O. Results: The Arterial walls of periodontitis group are significantly (p <0.05) thicker than the control group. the presence of collagen intimal disintegration, atheroma, stenosis, endothelial disintegration, lipid deposition and fatty emboly are also significantly (p<0,05) more in periodontitis group than in the control group. Conclusion: Periodontitis increase the risk of coronary atherosclerotic.

Keywords: Atherosclerosis Lesion, Periodontitis
Published
2015-05-02
How to Cite
NAFILAH, Roza; PRASETYA, Rendra Chriestedy; SUSILAWATI, I Dewa Ayu. Deteksi Lesi Aterosklerosis Koroner pada Model Tikus Periodontitis (Detection of Coronary Atherosclerotic Lesions in Periodontitis Rat Model). Pustaka Kesehatan, [S.l.], v. 3, n. 2, p. 217-223, may 2015. ISSN 2355-178X. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/2531>. Date accessed: 18 july 2019.
Section
Articles