Sintesis asam 2-(2-(4-kloro-N-(2,6-Diklorofenil)benzamida) fenil)asetat sebagai salah satu turunan diklofenak yang merupakan kandidat obat penghambat COX (siklooksigenase) (Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenil)benzamido)phenil)acetic acid as dic

  • Wahyu Novandari Herdiyanti Fakultas Farmasi Universitas Jember
  • Ayik Rosita Puspaningtyas Fakultas Farmasi Unviersitas Jember
  • Ika Oktavianawati Fakultas MIPA Universitas Jember

Abstract

Sodium diclofenac is an analgetic agent as an antimetabolite that used for treating pain. Several compound as a derivative diclofenac has been synthesis for increase its activity and reduce side effect. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid is a derivate of Sodium diclofenac that synthesized for development new drugs. Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic has benzoylation reaction between Sodium diclofenac and 4-Chlorobenzoil Chloride to give the target compound (2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid).This compound has been purified by Column Chromatography and give yellow color with melting point 143-145oC and then fix identification by H-NMR 400 MHz and KBr FTIR. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid can synthesized and resulted 8.39 % of yield.

 

Keywords: Sodium diclofenac, 2-(2-(4-Chloro-N-(2,6-dichlorophenyl)benzamido)phenyl)acetic acid, pain.

Published
2014-09-07
How to Cite
HERDIYANTI, Wahyu Novandari; PUSPANINGTYAS, Ayik Rosita; OKTAVIANAWATI, Ika. Sintesis asam 2-(2-(4-kloro-N-(2,6-Diklorofenil)benzamida) fenil)asetat sebagai salah satu turunan diklofenak yang merupakan kandidat obat penghambat COX (siklooksigenase) (Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenil)benzamido)phenil)acetic acid as dic. Pustaka Kesehatan, [S.l.], v. 2, n. 3, p. 427-431, sep. 2014. ISSN 2721-3218. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/2041>. Date accessed: 22 nov. 2024.
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Articles