Profile of Interleukin-4 and Interferon-γ of Balb/c Mice after Salivary Gland Extract of Anopheles sundaicus s.l. Vaccination and Infected by Plasmodium berghei-ANKA

  • Ali Machrus Jurusan Biologi FMIPA Universitas Jember
  • Adrial Adrial Fakultas Kedokteran Universitas Padang
  • Yunita Armiyanti Fakultas Kedokteran Universitas Jember
  • Hidayat Teguh Wiyono JurusanBiologi FMIPA Universitas Jember
  • Kartika Senjarini JurusanBiologi FMIPA Universitas Jember

Abstract

Malaria infection is initiated when sporozoites are inoculated into a vertebrate host via the salivary glands of an Anopheles mosquito. During Anopheles bite,  the salivary glands release components that include vasomodulator and immunomodulators. The salivary components of vectors have important role in transmission of pathogen. Therefore, if these components were injected repeatedly into a vertebrate host, it can stimulate host immune system and inhibit the transmission of the pathogen into the host. This could be observed the increasing level of  IFN-γ and decreasing level of IL-4 in mice model  of malaria after vaccination with  salivary gland ekstract (SGE) from An sundaicus s.l. It has also been proven that this  mechanisms was related with pathogen of malaria. This was supported by the reduction of parasitemie rate in those mice model after infection by P. Berghei.

 

Keywords: An sundaicus s.l., IFN-γ, IL-4,immunomodulators, salivary gland ,

TBV

Published
2014-07-23
How to Cite
MACHRUS, Ali et al. Profile of Interleukin-4 and Interferon-γ of Balb/c Mice after Salivary Gland Extract of Anopheles sundaicus s.l. Vaccination and Infected by Plasmodium berghei-ANKA. Jurnal ILMU DASAR, [S.l.], v. 15, n. 2, p. 75-80, july 2014. ISSN 2442-5613. Available at: <https://jurnal.unej.ac.id/index.php/JID/article/view/532>. Date accessed: 02 oct. 2022. doi: https://doi.org/10.19184/jid.v15i2.532.
Section
General