ANTIDIABETIC ACTIVITY OF POWDER AND ETHANOLIC EXTRACT OF ANTLION (Myrmeleon sp.) ON WISTAR STRAIN WHITE MALE RATS WITH GLUCOSE PRELOAD

Abstract

Diabetes mellitus (DM) is a group of metabolic
diseases characterized by hyperglycemia. It occurs
because abnormalities in insulin secretion, insulin
action, or both (Gustaviani, 2006). Diabetes
treatment is generally done through regular insulin
injections and delivery of oral antidiabetic drug such
as sulfonylurea class, biguanide, thiazolidinedion and
meglitinida which have some side effects like
headache, dizziness, nausea, anorexia and
permanent organ damage. More over, they are also
expensive. People start taking treatment in
traditional way natural materials, such as antlion
(Myrmeleon sp.,) to lower blood glucose level (Lee et
al., 2007).
Previous research showed that the young antlion
methanolic extract of had the highest inhibitory
activity toward α-glucosidase enzyme, was 22.81%
(Faiz, 2008). Giving combination of Antlion and
bananas for 14 days could decrease blood glucose
levels at a dose of 0,01ml / 200g (Tyas 2006).
This study has examined the antidiabetic effects of
the powder and ethanolic extract of antlion
(Myrmeleon sp.) on blood glucose level of Wistar
male rats were burdened by glucose.