Pengaruh Komposisi Hidroksi Propil Metil Selulosa K-15 dan Etil Selulosa N-22 terhadap Prosentase Kelembapan Air dan Pelepasan Meloksikam dari Sediaan Plester (The Influence of Hidroxy Propyl Methyl Cellulose K-15 and Ethyl Cellulose N-22 Ratio on Procent

  • Monica Iwud Rully Pramesthie Fakultas Farmasi, Universitas Jember Jln. Kalimantan 37, Jember 68121
  • Lidya Ameliana Fakultas Farmasi, Universitas Jember Jln. Kalimantan 37, Jember 68121
  • Budipratiwi Wisudyaningsih Fakultas Farmasi, Universitas Jember Jln. Kalimantan 37, Jember 68121

Abstract

The present research has been undertaken with the aim to develop a transdermal patch of meloxicam with ratio of hydroxy propyl methyl cellulose (HPMC) K-15 and ethylcellulose (EC)N-22 as a matrix were 1:9 (Formula 1), 2:8 (Formula 2), 3:7 (Formula 3).The physicochemical parameters like organoleptic and % moisture content were evaluated. Released test using dissolution apparatus were carried out in 500 mL of phosphate buffer saline pH 7.4 ± 0.05 at temperature 37 ± 0.5°C with speed of swirl 50 rpm. Results were analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (α = 0,05).The results of evaluation of patch dosage, transdermal patches were found yellow, odorless and dry. Result of moisture content F(1) 1.168 ± 0.009 %; F(2) 1.841 ± 0.019 % and F(3) 2.584 ± 0.025 %. Result of in vitro drug release F(1) 364.865 ± 0.701 µg/cm2.menit1/2; F(2) 397.212 ± 0.441 µg/cm2.menit1/2 and F(3) 439.277 ± 0.559 µg/cm2.menit1/2. It can be concluded that the combination ofHPMC K-15 and EC N-22 at ratio 7:3 was the best choice for manufacturing transdermal patch based on physicochemical and the release profile.

 

Keywords: transdermal patch, meloxicam, hydroxypropylmethyl celulosa, ethylcellulosa

Published
2014-01-10
How to Cite
PRAMESTHIE, Monica Iwud Rully; AMELIANA, Lidya; WISUDYANINGSIH, Budipratiwi. Pengaruh Komposisi Hidroksi Propil Metil Selulosa K-15 dan Etil Selulosa N-22 terhadap Prosentase Kelembapan Air dan Pelepasan Meloksikam dari Sediaan Plester (The Influence of Hidroxy Propyl Methyl Cellulose K-15 and Ethyl Cellulose N-22 Ratio on Procent. Pustaka Kesehatan, [S.l.], v. 2, n. 1, p. 175-178, jan. 2014. ISSN 2721-3218. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/817>. Date accessed: 21 jan. 2022.
Section
Articles