Optimasi Polyvinilpyrolidone K-30 dan Sodium Starch Glycolate pada Tablet Likuisolid Simvastatin dengan Desain Faktorial

  • Agne Yuliana Nursatriya Fakultas Farmasi Universitas Jember
  • Lusia Oktora Ruma Kumala Sari Fakultas Farmasi Universitas Jember
  • Dwi Nurahmanto Fakultas Farmasi Universitas Jember
DOI: https://doi.org/10.19184/pk.v11i3.18320

Abstract

The liquisolid technique is one way to increase the drug dissolution rate, which has low solubility in water and can improve drug flow properties. This research aims to determine the optimum composition of a combination of polymer PVP K-30 and SSG on a liquisolid simvastatin tablet with a factorial design. The factorial design method is used to determine the effect of the concentration of two factors, namely PVP K-30 and SSG, on the response of hardness, friability, disintegration time, and dissolution. PVP K-30 acts as a binder, and SSG works as a disintegration, determines the optimum formula using expert design software version 1. The result showed that all formulas meet the requirements of hardness values (4-8 kg), friability (<1%), disintegration time of no more than 15 minutes, and dissolution in 30 minutes. The use of PVP K-30 concentration of 6 mg and SSG 24 mg indicated the optimum formula with a desirability value of 0,806.

References

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Published
2024-08-08
How to Cite
NURSATRIYA, Agne Yuliana; SARI, Lusia Oktora Ruma Kumala; NURAHMANTO, Dwi. Optimasi Polyvinilpyrolidone K-30 dan Sodium Starch Glycolate pada Tablet Likuisolid Simvastatin dengan Desain Faktorial. Pustaka Kesehatan, [S.l.], v. 11, n. 3, p. 200-206, aug. 2024. ISSN 2721-3218. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/18320>. Date accessed: 22 nov. 2024. doi: https://doi.org/10.19184/pk.v11i3.18320.
Citation Formats
Issue
Vol 11 No 3 (2023): Volume 11 No.3, 2023
Section
Articles
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