Daya Hambat Ekstrak Kulit Semangka (Citrullus lanatus) Terhadap Pertumbuhan Candida albicans

  • Nindya Nur Maghfiroh Fakultas Kedokteran Gigi Universitas Jember
  • Ayu Mashartini Prihanti Fakultas Kedokteran Gigi Universitas Jember
  • Purwanto Purwanto Fakultas Kedokteran Gigi Universitas Jember

Abstract

Candida albicans is normal flora found in the oral mucosa in healthy individuals but has opportunistic pathogenic properties. The change in the oral cavity's environmental conditions can cause C. albicans to turn into a pathogen and cause oral candidiasis. Antifungal drugs that are common used for the treatment of oral candidiasis are topical nystatin preparations. Nystatin is an antifungal drug from the polyene group produced by Streptomyces noursei, which is thought to be very effective in treating diseases caused by C. albicans with a success rate 79.6 - 87.5%. The previous study showed that watermelon peel extract contains active compounds of alkaloids, flavonoids, tannins, and saponins. The active compound is known to have antifungal activity. The study aimed to determine the ability of watermelon peel extract to inhibit the growth of C. albicans. The type of research conducted is experimental laboratories using the post-test only control group design. The observations in this study about the inhibitory power of watermelon rind extract (Citrullus lanatus) on the growth of C. albicans showed that there were inhibitory zones of watermelon skin extract on the growth of C. albicans.

References

[1] Nur’aeny N, Hidayat W, Dewi TS, Herawati E, dan IS. Wahyuni. 2017. Profil oral candidiasis di bagian ilmu penyakit mulut rshs bandung periode 2010-2014. 3 (1).
[2] Lestari PE. 2010. Peran faktor virulensi pada patogenesis infeksi Candida albicans. Stomatognatic (J.K.G Unej). 7 (2): 113-117.
[3] Maharani S, dan Santoso O. 2012. Pengaruh pemberian ekstrak siwak (Salvadora persica) pada berbagai konsentrasi terhadap pertumbuhan Candida albicans. Jurnal PDGI. (2): 61-64.
[4] Sari DNR, dan Susilo DK. 2017. Perbandingan kemampuan ekstrak kulit pisang agung semeru dan pisang mas kirana varietas lumajang dalam menghambat pertumbuhan Candida Albicans. Jurnal Florea. 4(2).
[5] Lyu X, Chen Z, Zhi MY, dan Hua H. 2016. Efficacy of nystatin for the treatment of oral candidiasis: A Systematic Review and Meta-Analysis. Drug Des Devel Ther.10: 1161–1171.
[6] Fauziah GF. 2014. Perbedaan potensi antijamur ekstrak etanolik kulit manggis (Garcinia Mangostana L.) dengan nistatin terhadap C. Albicans in vitro. Skripsi. Yogyakarta: Fakultas Kedokteran Gigi Universitas Gadjah Mada.
[7] Akpan A, dan Morgan R. 2016. Oral candidiasis. Postgrad Med J: 78:455–459.
[8] Candrasari A, Romas MA, Hasbi M, dan Astuti OR. 2012. Uji daya anti mikroba ekstrak daun sirih merah (Piper crocatum Ruiz dan pav.) terhadap pertumbuhan Staphylococcus aureus ATCC 6538, Eschericia coli ATCC 11229 dan Candida albicans ATCC 10231 secara in vitro. Biomedika 4(1): 9-16
[9] Ismayanti, Bahri S, dan Nurhaeni. 2013. Kajian kadar fenolat dan aktivitas antiosidan jus kulit buah semangka (Citrullus lanatus). Online Jurnal of Natural Science. 2(3): 100-110.
[10] Muthia R, Amalia A, Rizaldi MP, dan Amadia. 2017. Uji aktivitas in vivo ekstrak etanol kulit buah semangka (Citrullus lanatus L.) sebagai diuretik dengan pembanding furosemid. Jurnal Borneo Journal of Pharmascientech. 01 (01).
[11] Kurniawati A, Mashartini A, dan Fauzla IF. 2016. Perbedaan khasiat anti jamur antara ekstrak etanol daun Kersen (Muntingia calabura L.) dengan nistatin terhadap pertumbuhan Candida albicans.
[12] Sobir SFD. 2010. Budidaya Semangka Panen 60 Hari. Jakarta: Penebar Swadaya.
[13] Abad MJ, Ansuategui M. and Bermejo P. 2007. Active antifungal substances from natural sources. Arkivoc. 2: 116-145.
[14] Watson RR, dan Preedy VR. 2007. Bioactive Foods in Promoting Health: Probiotics and Prebiotics. USA: Academy Press.
[15] Hakim L, dan Ramadhian R. 2015. Kandidiasis oral. 4 (9).
[16] Asmardi A, Roza RM, Fitmawati. 2014. Aktivitas Antibakteri Ekstrak Daun Cyclea Barbata (l.) Miers. terhadap Bakteri Escherichia coli dan Salmonella typhi. JOM FMIPA. 1(2): 1-9.
[17] Johnson JT, Iwang EU, Hemen JT, Odey MO, Efiong EE, and Eteng OE. 2012. Evaluation of anti-nutrient contents of watermelon Citrullus lanatus.Scholars Research Library.3: 5145-5150.
[18] Kicklighter SD. 2002. Antifungal Agents and Fungal Prophylaxis in The Neonate. Neo Reviews. 3:249-54.
Published
2021-01-16
How to Cite
MAGHFIROH, Nindya Nur; PRIHANTI, Ayu Mashartini; PURWANTO, Purwanto. Daya Hambat Ekstrak Kulit Semangka (Citrullus lanatus) Terhadap Pertumbuhan Candida albicans. Pustaka Kesehatan, [S.l.], v. 9, n. 1, p. 54-59, jan. 2021. ISSN 2721-3218. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/10825>. Date accessed: 01 aug. 2021. doi: https://doi.org/10.19184/pk.v9i1.10825.