PENGARUH EKSTRAK N-HEKSANA DAGING BUAH DELIMA PUTIH (PUNICA GRANATUM) TERHADAP PENURUNAN KADAR KOLESTEROL DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS L.) DAN PEMANFAATANNYA SEBAGAI BUKU SUPLEMEN

Abstract

ABSTRACT : Cholesterol is a type of fat in the blood , but high concentrations of cholesterol can cause atherosclerosis which will have an impact on coronary heart disease. One of the alternative treatments for lowering blood cholesterol levels are  pomegranate white (Punica granatum). The purpose of this study was to determine the effect of n-hexane extract of pomegranate white to the reduction of blood cholesterol levels in white rats (Rattus norvegicus L.) and the experiment’s result can be used as a supplement book. In this experiment using animals, white rats (Rattus norvegicus L.) male, strain Wistar, aged 3-4 months and weight 150-200 grams, consisting of 6 treatments with 4 repetitions; P1 (ekstract n-hexane 50 µL) , P2 (extract n-hexane 55 µL), P3 (extract n-hexane 60 µL), and P4 (freshly squeezed pomegranate white 1 mL), control (-) with aquadest and control (+) with 0.72 mg simvastatin mg/day. The results showed that extract n-hexane of pomegranate white decreasing blood cholesterol levels of white rats (Rattus norvegicus L.) but not significantly (p = 0.266). From the results of the validation test book supplement, showed that supplement’s book with the title "White Pomegranate-Lowering Cholesterol Without Side Effects" can use for suplement’s book.

Key Words : White Pomegranate, Blood Cholesterol, Suplement’s Book