• Nadyatul Ilma Indah Savira Biology Education Study Program, Faculty of Teacher Training and Education, University of Jember
  • Sri Puji Astuti Wahyuningsih Biology Department, Faculty of Sains and Technology, Airlangga University email: sri-p-a-w@fst.unair.ac.id
  • Dewi Rahmawati Biology Department, Faculty of Sains and Technology, Airlangga University email: sri-p-a-w@fst.unair.ac.id


Staphylococcus aureus is an opportunistic pathogen and cause of nosocomial infection, which has leukocidin and can reduce immunity. Because of antibiotic resistance, immunomodulator is an alternative treatment for S. aureus infection. Polysaccharide krestin (PSK) from Coriolus versicolor extract contains active β-glucan that triggers immune responses' effectiveness including phagocytosis. This research aimed to know the activity of PSK against phagocytosis ability on mice infected by S. aureus. There were six treatment groups. 100 mg/kg BW PSK was given to the mice strain Balb/C by gavage. S. aureus was infected once every two weeks. Phagocytosis ability consisted of phagocytic activity and capacity, counted on slide smears of mice intraperitoneal fluid. The results showed that PSK increased phagocytic activity in the group giving PSK after infection. Furthermore, the most effective giving PSK on phagocytic capacity was before and after infection. Based on this research, PSK increased immunity by phagocytosis ability and can be useful as an immunomodulator.


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How to Cite
SAVIRA, Nadyatul Ilma Indah; WAHYUNINGSIH, Sri Puji Astuti; RAHMAWATI, Dewi. POLYSACCHARIDE KRESTIN ACTIVITY FROM Coriolus versicolor EXTRACT AGAINST PHAGOCYTOSIS ABILITY ON MICE INFECTED BY Staphylococcus aureus. BIOEDUKASI: Jurnal Biologi dan Pembelajarannya, [S.l.], v. 19, n. 1, p. 37-41, apr. 2021. ISSN 2580-0094. Available at: <https://jurnal.unej.ac.id/index.php/BIOED/article/view/22139>. Date accessed: 19 june 2021. doi: https://doi.org/10.19184/bioedu.v19i1.22139.

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