EFFECT OF ETHANOLIC EXTRACT OF Annona muricata L SEEDS POWDER TO DECREASE BLOOD GLUCOSE LEVEL OF WISTAR MALE RATS WITH GLUCOSE PRELOAD

Abstract

Based on data from World Health Organization
(WHO) diabetes mellitus was the direct cause of death of
1.5 million people, more than 80% of deaths due to
diabetes occurs in middle-income countries and low
(WHO, 2014). According to the Basic Health Research
(Riskesdas) in 2013, the incidence of diabetes mellitus in
Indonesia increased by two times greater than in 2007.
Annona muricata L is used as a traditional
medicine to lower blood glucose levels with contain
tannin, phytosterols, calcium oxalate, alkaloids murisin
(Arief and Hariana, 2006), flavonoids and essential oils
(Surbakti, 1994). Flavonoid compounds have an
important role in the prevention of diabetes and its
complications (Jack, 2012). Previous research showed
that bark of plants soursop has a most excellent efficacy
compared with the roots and leaves of the Annona
muricata L in lowering blood glucose levels in male rats
induced streptozozin (Rahmawati, 2014).
This study aimed to examine the effect of
ethanolic extract of Annona muricata L. seeds powder on
decreasing blood glucose level in wistar strain male rat
with glucose loading.