EFFECT OF SOLID LIPID NANOPARTICLE (SLN) AND NANO STRUCTURE LIPID CARRIER (NLC) SYSTEM ON ANTIOXIDANT STABILITY OF TOMATO EXTRACT (LIPID: CETYL ALCOHOL AND ISOPROPYL MYRISTATE)

Abstract

Tomato extract was known contains many
antioxidants (Chauhan et al., 2010), such as
lycopene, that are easily degraded by UV-B rays. The
mechanism lycopene as an antiaging is to reduce
skin regeneration and increase the thickness of the
epidermis (Sahasrabuddhe, 2011). As an
antioxidant, lycopene easily degraded when exposed
to light, heat, and oxygen (Chauhan et al., 2011).
Drug delivery system based on nanolipid carrier
system, such as: Solid Lipid Nanoparticles (SLN) was
appropriate to stabilize lycopene, as lipophilic
substance (Wissing and Muller, 2003; Helgason et
al., 2009; and Okonogi dan Riangjanapatee, 2014).
One of the limitations of SLN is the drug molecule
that has been trapped expulsed easily during
storage. It is caused of the orderdness of lattice lipid
crystal. Replacement part of solid lipid using liquid
lipid (called as nanostructure lipid carriers or NLC)
can reduce the orderdness of lattice lipid crystall and
it will repaired it (Kaur et al, 2015).
In this research have been tried to be compared the
ability of SLN and NLC to improve the stability of
antioxidant tomato extract. Using 20% total amount
of lipid, extract tomato-SLN made from cetyl alcohol
as solid lipid and extract tomato-NLC made from
difference ratio between cetyl alcohol and isopropyl
myristate (IPM) such as: 9:1 and 7:3. Tween 80 and
Kollipor were used as surfactant and co-surfactant.
IPM was choose because of its enhancer and
emollient effect so easily to apply to the skin
(Vadgama et al, 2015).