The Influence of Indonesian Cardio Gymnastic Series-I to Plasma Protein Expression Of BDNF in The Elderly
Abstract
Physical activity in the elderly will improve cognitive function. Biomolecular changes to see an increase in elderly cognitive function are characterized by an increase in the expression of plasma protein Brain Derived Nerve Factor (BDNF). Efforts to improve cognitive function can be done in Indonesian Cardio Gymnastic Serie-I . In this study the aim was to analyze the influence of Indonesian Cardio Gymnastic Serie-I three times a week for 6 weeks to Plasma Protein Expression of BDNF in Elderly. This study used a pre-experiment with the design of one group pre and post test for 27 samples of healthy elderly aged > 60 years and routinely conduct Indonesian Cardio Gymnastic Serie-I 3 times a week for 6 weeks. To determine BDNF levels taken from elderly plasma blood then measured using the Enzime Link Immunosorbent Assay (ELISA) method. To analyze the influence of Indonesian Cardio Gymnastic Serie-I to plasma protein expression of BDNF, a paired t-test was used so that the mean differences between before and after gymnastics were known. There were differences in the mean BDNF plasma protein expression before and after Indonesian Cardio Gymnastic Serie-I (2174,52 ± 700,79 VS 1981 ± 915,17 pg/ mL, p = 0,40 ; p > 0,05) with the mean difference was 192,69 which means Indonesian Cardio Gymnastic Serie-I 3 times a week for 6 weeks had no influence to plasma protein expression of BDNF because the level has decreased by 91.14% after exercising
References
Anonym. 2010. Buku Petunjuk Senam Jantung Sehat Seri II. Jakarta. http//:www.yayasanjantungindonesia.com. 2001. Diakses tanggal 15 April 2010.
Chung, W., Baguet, A., Bex, T., Bishop, D.J and Derave, W. 2014. International Journal of Sport Nutrition and Exercise Metabolism, 24 (3), 315-324.
Departement of Health. 2012. Exercise Prescription : Doctor’s Handbook.
Dinoff, A., Herrmann, N., Swardfager, W., et al. 2016. The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis. PLoS One, 11(9) :e0163037. Published 2016 Sep 22. doi:10.1371/journal.pone.0163037
Erickson, K.I., Miller, D.L., Roecklein, K.A. 2012. The aging hippocampus: Interactions between exercise, depression, and BDNF. Neuroscientist, 18 , 82–97.
Firth, J., Stubbs, B., Vancampfort, D., Schuch, F., Lagopoulos, J., Rosenbaum, S., et al. 2018. Effect of aerobic exercise on hippocampal volume in humans: a systematic review and meta-analysis. Neuroimage.166,230–8. doi:10.1016/j. neuroimage.2017.11.007.
Forti, L.N., Roie, E.V., Njemini, R., Coudyzer, W., Beyer, I., Delecluse, C & Bautmans I. 2015. Dose-and gender-specific effects of resistance training on circulating levels of brain derived neurotrophic factor (BDNF) in community-dwelling older adults. Experimental gerontology, 70, 144-9.
Hayashi, J., Decherrie, L. 2016. Geratric Home-Based Medical Care: Principle and Practice. Springer, 125–3.
Kerling, A., Kück, M., Tegtbur, U., Grams, L., Weber-Spickschen, S., Hanke, A., et al. 2017. Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder. J Affect Disord, 215(215),152–5. doi:10.1016/j.jad.2017.03.034
Laing, K.R., Mitchell, D., Wersching, H., Czira, M.E., Berger, K., Baune, B.T. 2012. Brain-Derived Neurotrophic Factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the Memo Study Age, 34 (4), 1011–22.
Lalarni, H.K.2015. Pengaruh Senam Jantung Sehat Seri V terhadap Kebugaran dan Lemak Tubuh pada Anggota Posyandu Lansia Amrih Sehat Kec.Bergas Semarang.
Leckie. 2014. BDNF mediates improvements in executive function following a1- year exercise intervention. Frontiers in Human Neuroscience, 8, 985.
Liu, P.Z., Nusslock, R. 2018. Exercise-mediated neurogenesis in the hippocampus via BDNF. Front Neurosci, 12(Feb), 1–6.
Martinson, M., Berridge, C. 2015. Successful aging and its discontents: A systematic review of the social gerontology literature. Gerontologist, Vol 55 No.1, 58–69.
Masruroh. 2014. Efek Aktivitas Berjalan Kaki Terstruktur Dalam Memelihara Fungsi Kognitif pada Usia Lanjut : Uji Klinis Acak Tersamar Tunggal. Universitas Indonesia.
Muzamil, M.S., Martini, RS.2014. Hubungan antara tingkat Aktivitas Fisik dengan Fungsi Kognitif pada Usila di Kelurahan Jati Kecamatan Padang Timur. Jurnal Kesehatan Andalas, 3 (2).
Republik Indonesia.2016. Kementrian Kesehatan. Pusat Data dan Informasi Kementrian Kesehatan RI. Situasi dan Analisa Lanjut Usia. Jakarta Selatan.
Sari, E., Sari, S., & Pratiwi, S. (2018). Community Self-Efficacy of Coronary Heart Disease Based on Characteristic Risk Factors.NurseLine Journal, 3(2), 65-71. doi:10.19184/nlj.v3i2.8341
Sundari, M.J., Suhadi, Maryati. 2014. Pengaruh Senam Lansia terhadap Penurunan Tekanan Darah Lansia di Panti Wreda Usia Bethany Semarang.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
