Analisis In Vivo Aktivitas Antihipertensi dari Protein Biji Melinjo (Gnetum gnemon) Terhidrolisis

  • Yeni Tri Puspitaningrum Fakultas Kedokteran, Universitas Jember
  • Erfan Efendi Fakultas Kedokteran, Universitas Jember
  • Tri Agus Siswoyo DAST (Center for Development of Advanced Sciences and Technology), Universitas Jember

Abstract

Hypertension is a serious health problem and requires a good handling. An alternative treatment for hypertension is required due to the treatment of hypertension took a long period of time causing unwanted side effects. Melinjo seed hydrolyzed-proteins have an ACE-inhibitor activity, an antihypertensive effect. This study aimed to determine the antihypertensive effects of melinjo seed hydrolyzed-proteins in hypertensive rats. Wistar rats induced with prednisone 1,5 mg/kg body weight and 2% NaCl for 7 days and then treated. There were 7 groups: a normal group K, a group K(-) which is a hypertensive rats without treatment, a group K(+) which is hypertensive rats with captopril 2,5 mg/kg body weight on day 8th, and four treatment groups P1, P2, P3, and P4 which are hypertensive rats with melinjo seed hydrolyzed-proteins with a dose of 5, 10, 20, and 30 mg/kg body weight on day 8th, respectively. Blood pressure was measured before and after treatment every 1 hour for 5 hours. The results showed that melinjo seed (Gnetum gnemon) hydrolyzed-proteins can decrease blood pressure in hypertensive rats.

 

Keywords: Antihypertensive, Gnetum gnemon, Hydrolized-Protein, Blood Pressure

Published
2014-05-03
How to Cite
PUSPITANINGRUM, Yeni Tri; EFENDI, Erfan; SISWOYO, Tri Agus. Analisis In Vivo Aktivitas Antihipertensi dari Protein Biji Melinjo (Gnetum gnemon) Terhidrolisis. Pustaka Kesehatan, [S.l.], v. 2, n. 2, p. 327-331, may 2014. ISSN 2721-3218. Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/1902>. Date accessed: 22 nov. 2024.
Citation Formats
Issue
Vol 2 No 2 (2014)
Section
Articles

e-Journal Pustaka Kesehatan has CC-BY-SA or an equivalent license as the optimal license for the publication, distribution, use, and reuse of scholarly work. Authors who publish with this journal retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.