Efek Pati Resisten Singkong (Manihot esculenta Crantz) terhadap Indeks HOMA-IR dan HOMA-B Tikus Model Diabetes
Abstract
Insulin resistance is a condition in which target organs fail to respond normally to insulin. Cassava contains 9,69 percent starch that resist to digestive enzyme in intestine and has been shown to increase insulin sensitivity and enhance β cell function. The aim of this study was to analyze the difference effect of native cassava starch and cassava resistant starch consumption on insulin resistance and β cell function indexes. This study was quasy experimental research with post-test only control group design using 16 male wistar strain rats divided into four groups: K1 (normal rats with standard diet), K2 (diabetic rats with standard diet), P1 (diabetic rats with native cassava starch diet) and P2 (diabetic rats with cassava resistant starch diet). The rats were fed with high fat diet and injected with low-dose streptozotocin to mimic the patogenesis of type 2 diabetes. The rats were then fed with assigned diet for 28 days. The data collection was obtained from laboratory examination of fasting plasma glucose and fasting plasma insulin to determine HOMA-IR and HOMA-B indexes. Post Hoc analysis showed no difference in both indexes between native cassava starch and cassava resistant starch fed groups (p>0,05).
References
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[27]Farilla L, Bulotta A, Hirshberg B, Calzi SL, Khoury N, Noushmehr H, et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology [Internet]. 144(12): 5149-58. 2003 Des [Cited 2017 Des 12]. Available from: https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2003-0323
[28]Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H. A prospective analysis of the HOMA model: the Mexico City diabetes study. Diabetes Care [Internet]. 19: 1138–1141. 1996 Oct [Cited 2017 Des 12]. Available from: https://www.ncbi.nlm.nih. gov/pubmed/8886564.
[2] Aggasarah AB. Rasio prevalensi resistensi insulin pada subjek dengan obesitas abdominal. Yogyakarta: Universitas Gajah Mada; 2015.
[3] Roden M. How free fatty acids inhibit glucose utilization in human skeletal tissue. News Physiol Sci [Internet]. 19: 92-96. 2004 Jun [cited 2017 Oct 14]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15143200
[4] Soriano AA, Cruz-Cordero RD, Rosado JL, Gasca TG. 4-hydroxyisoleucine from fenugreek (Trigonella foenum-graecum): effects on insulin resistance associated with obesity. Molecules [Internet]. 21(11): [about 12pp]. 2016 Nov [cited 2017 Oct 14]. Available from: http://www.mdpi.com/ resolver?pii=molecules21111596
[5] Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr [Internet]. 82(3): 559-67. 2005 Sept [cited 2017 Oct 14]. Available from: http://www.ajcn.org/cgi/ pmidlookup?view=long&pmid=16155268
[6] Merendino JJ, Jibrin J. The Best Life Guide to Managing Diabetes and Pre-Diabetes. New York: Simon & Schuster; 2009.
[7] Mochizuki K, Sato Y, Takase S, Goda T. Changes in mucosal a-glucosidase activities along the jejunal-ileal axis by an Hm-HACS diet intake are associated with decreased lipogenic enzyme activity in epididymal adipose tissue. J Agric Food Chem [Internet]. 58: 6923-7. 2010 Jun [cited 2017 Oct 14]. Available from: https://www.ncbi. nlm.nih.gov/pubmed/20481469
[8] Zhou J, Martin RJ, Tulley RT, Raggio AM, McCutcheon KL, et al. Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Phisiol Endocrinol Metab [Internet]. 295(5): E1160-6. 2008 Nov [cited 2017 Oct 14]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/ 18796545
[9] Shen L. Dietary resistant starch improve maternal glycemic control in Goto-Kakizaki rat. USA: Lousiana State University; 2010.
[10] Setiarto RH, Jenie BS, Faridah DN, Saskiawan I. Kajian peningkatan pati resisten yang terkandung dalam bahan pangan sebagai prebiotik. Jurnal Ilmu Pertanian Indonesia [Internet]. 20 (3): 191-200. 2015 Des [cited 2017 Oct 14]. Available from: http://journal.ipb.ac.id/index.php/JIPI/article/view/10730/8297
[11] Antunes LC, Elkfury JL, Jornada MN, Folleto KC, Bertoluci MC. Validation of HOMA-IR in a model of insulin-resistance induced by a high-fat diet in wistar rats. Am J Physiol Endocrinol Metab [Internet]. 60 (2): 138-42. 2016 Apr [cited 2017 Oct 14]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/ 27191048
[12] Wang Z, Yang Y, Xiang X, Zhu Y, Men J, He M. Estimation of the normal range of blood glucose in rats. Wei Shen Yan Jiu [Internet]. 39(2): 133-137. 2010 Mar [cited 2017 Oct 14]. Available from: https://www.ncbi.nlm. nih.gov/pubmed/20459020
[13] Cacho J, Sevillano J, de Castro J, Herrera E, Ramos MP. Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats. Am J Physiol Endocrinol Metab [Internet]. 295(5): E1269-76. 2008 Nov [cited 2017 oct 14]. Available from: https://doi.org/10.1152/ajpendo.90207.2008
[14] Song Y, Manson JE, Tinker L, Howard BV, Kuller LH, Nathan L, et al. Insulin sensitivity and insulin secretion determined by homeostasis model assessment (HOMA) and risk of diabetes in a multiethnic cohort of women: the women’s health initiative observational study. Diabetes Care [Internet]. 30(7): 1747-1752. 2007 Jul [Cited 2017 Des 12]. Available from: http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=17468352
[15] Rhama D, Astuti D, Lusiawati S. Daya cerna pati. Bogor: Institut Pertanian Bogor; 2014.
[16] Kustyawati ME, Sari M, Haryati T. Efek Fermentasi dengan Saccharomyces cereviceae terhadap karakteristik biokimia tapioka. Agritech [Internet]. 33(3): 281-7. 2013 Aug [cited 2017 Oct 14]. Available from: https://jurnal.ugm.ac.id/agritech/article/ view/9549/7124
[17] Nasoetion A, Damayanti E. Ilmu gizi dasar. Bogor: Institut Pertanian Bogor; 2008.
[18] Almatsier S. Prinsip dasar ilmu gizi. Jakarta: Gramedia Pustaka; 2009.
[19] Faridah DN, Rahayu WP, Rahadi MS. Modifikasi pati garut (Marantha arundinacea) dengan perlakuan hidrolisis asam dan siklus pemanasan-pendinginan untuk menghasilkan pati resisten tipe 3. Jurnal Teknologi Industri Pertanian [Internet]. 23 (1):61-69. 2013 [cited 2017 Nov 8]. Available from: http://journal.ipb. ac.id/index.php/jurnaltin/article/view/7235/5654
[20] Sa’adah NN, Purwani KI, Nurhayati APD, Ashuri NM. Analysis of lipid profile and atherogenic index n hiperlipidemic rat (Rattus norvegicus Berkenhout, 1796) that given the methanolic extract of parijoto (Medinilla speciosa). AIP Conference Proceedings 1984 [Internet]. 2017 Jun [cited 2017 Nov 8]. Available from: http://aip.scitation.org/doi/pdf/10.1063/1.4985422
[21] Polat ES, Citil OB, Garip M. Fatty acid composition of yolk of nine poultry species kept in their natural environment. Anim Sci Pap Rep [Internet]. 31(4): 363-68. 2013 Apr [cited 2017 Nov 8]. Available from: http://www.ighz.edu.pl
[22] Shimano H. SREBPs: physiology and pathophysiology. The FEBS Journal [Internet]. 276(3): 616–21. 2008 Feb [cited 2017 Nov 8]. Available from: http://dx. doi.org/10.1111/j.1742-4658.2008.06806.x
[23] Gutch M, Kumar S, Razi SM, Gupta KK, Gupta A. Assessment of insulin sensitivity/ resistance. Indian J Endocrine Metab [Internet]. 19(1): 160-164. 2015 [Cited 2017 Des 12]. Available from: http://www.ijem.in/ text.asp?2015/19/1/160/146874
[24] Herawati H. Potensi pengembangan produk pati tahan cerna sebagai pangan fungsional. Jurnal Litbang Pertanian [Internet]. 30(1): 31-9. 2011 [cited 2017 Nov 8]. Available from: http://ejurnal.litbang.pertanian.go.id/ index.php/jppp/article/view/3444/2918
[25]Jeon, SM. Regulation and function of AMPK in physiology and diseases. Experimental and Molecular Medicine [Internet]. 48:e246. 2016 Jul [Cited 2017 Des 12]. Available from: https://www.nature.com/articles/emm 201681.ris
[26]Stoffers DA, Desai BM, DeLeon DD, Simmons RA. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes [Internet]. 52(3): 734-40. 2003 Mar [Cited 2017 Des 12]. Available from: http://diabetes.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=12606515
[27]Farilla L, Bulotta A, Hirshberg B, Calzi SL, Khoury N, Noushmehr H, et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology [Internet]. 144(12): 5149-58. 2003 Des [Cited 2017 Des 12]. Available from: https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2003-0323
[28]Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H. A prospective analysis of the HOMA model: the Mexico City diabetes study. Diabetes Care [Internet]. 19: 1138–1141. 1996 Oct [Cited 2017 Des 12]. Available from: https://www.ncbi.nlm.nih. gov/pubmed/8886564.
Published
2020-04-26
How to Cite
ULFA, Maria et al.
Efek Pati Resisten Singkong (Manihot esculenta Crantz) terhadap Indeks HOMA-IR dan HOMA-B Tikus Model Diabetes.
Pustaka Kesehatan, [S.l.], v. 7, n. 1, p. 1-7, apr. 2020.
ISSN 2721-3218.
Available at: <https://jurnal.unej.ac.id/index.php/JPK/article/view/17586>. Date accessed: 24 apr. 2024.
doi: https://doi.org/10.19184/pk.v7i1.17586.
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