Journal of Agromedicine and Medical Sciences
https://jurnal.unej.ac.id/index.php/JAMS
<p><strong>ABOUT THE JOURNAL</strong></p> <p>The Journal of Agromedicine and Medical Sciences (AMS) is a four-month periodical journal (February, June, and October) that contains various articles in the form of research, systematic reviews, and case report in the field of medicine with a focus on basic medical sciences, clinical medicine, and agromedicine. All manuscripts submitted must contain original research that was not previously published and is not being considered for publication elsewhere. All authors have read and agreed to the contents of the manuscript, and that every experimental study reported in the manuscript has been carried out with the approval of the ethics committee. </p> <p>Articles are published on a first-come, first-served basis. The members of the editorial board have the right to recommend the expedited publishing of articles which are deemed to be a priority and have received good reviews. Articles which have been received by the editorial board are assessed by the board members and then sent for external review. The selection of articles published on AMS uses a double blind peer-review system. The review process is carried out within a maximum of 1 month for one review round. The choice of reviewers is up to the editorial board.</p> <p>The manuscript is sent on to reviewers who are experts in this field of research, and the editorial board makes its decisions based on the reviews of these experts. The decision can be categorized into 4, articles accepted without improvement (Accepted Submission), articles need revision from the author before acceptance (Required Revision), the author must make fundamental improvements and the article will go through the review process again (Resubmit for Review), and the article does not acceptable for publication (Decline Submission). Authors who do not correct the article within one month are automatically considered to cancel the publication and also cancel all previous acceptance statements. The return of an article to the authors for improvement does not mean that the article has been accepted for publication. After the revised text has been received, a decision is made by the editorial board. The author must return the improved text, together with the responses to all comments of the reviewer. After the layout for the relevant issue of the journal is ready, the publisher sends out galley files to the authors for a final review (proofreading). Changes other than simple corrections in the text, figures, or tables are not allowed at the final review stage. If this is necessary, the issue is resolved by the editorial board.</p> <!-- /wp:tadv/classic-paragraph -->Faculty of Medicine, University of Jemberen-USJournal of Agromedicine and Medical Sciences2460-9048 Cover AMS Vol. 10 No. 1 (2024)
https://jurnal.unej.ac.id/index.php/JAMS/article/view/46873
<p>.</p>Zahrah Febianti
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2024-03-022024-03-02101 Editorial Board
https://jurnal.unej.ac.id/index.php/JAMS/article/view/46874
<p>.</p>Zahrah Febianti
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2024-03-022024-03-02101 Ventricular Septal Defect And Maternal History Of Epilepsy: A Case Report
https://jurnal.unej.ac.id/index.php/JAMS/article/view/44182
<p><em>Pregnancy with epilepsy can cause major risks for both the mother and the offspring. It is known that the use of antiepileptic drugs (AEDs) during pregnancy can increase the risk of cardiac malformations. This journal reports a 19-day-old male infant who came with complaints of shortness of breath and a blue lip 2 days before admission. The mother had a history of epilepsy and had regularly taken epilepsy medication since before pregnancy. Physical examination revealed cyanotic lips, chest wall retraction, coarse crackles, and murmurs. The patient's symptoms and signs were associated with congenital heart disease, so he was further observed in the NICU. After bedside echocardiography, the results showed a patent foramen ovale and perimembranous ventricular septal defect. The teratogenic effect of AED is thought to be one of the major causative factors of congenital heart disease. A ventricular septal defect is the most common cardiac malformation found in population-based studies. The long-term effects of AED exposure during pregnancy require further investigation, both in terms of the type of AED (old or new) and the duration of AED consumption. It is important to educate mothers-to-be about this, especially to avoid the risk of congenital heart disease in their offspring.</em></p> <p><strong><em>Keywords</em></strong><em>: epilepsy, ventricular septal defect, cardiac malformation.</em></p>Ngurah Agung Reza Satria Nugraha PutraNyoman SuciawanIda Bagus Komang Arjawa
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2024-03-012024-03-011011410.19184/ams.v10i1.44182 Approach to Refractory Hypoglycaemia in a Patient with Hepatocellular Carcinoma: A Case Study and Literature Review
https://jurnal.unej.ac.id/index.php/JAMS/article/view/45924
<p>Symptomatic hypoglycaemia in patients without underlying diabetes is uncommon. Etiology of non-diabetic hypoglycaemia varies from hyperinsulinism, hormone deficiencies, malignancies, to critical illness. This case report illustrates the attempt to determine the cause of refractory hypoglycaemia in a 46 years old male patient with underlying hepatocellular carcinoma (HCC). Anamnesis and examinations have narrowed differential diagnosis to concurrent systemic illness (liver failure due to HCC) or paraneoplastic syndrome from non-beta cell tumors, referred as non-islet cell tumor hypoglycaemia (NICTH). It was noted that the absence of chronic liver disease stigmata has put NICTH as the possible main cause. Deciding what diagnostic modalities needed to perform to establish the diagnosis eventually relies on clinical judgement while taking cost-effectiveness and patients’ preference in consideration, particularly in low-resource settings. Nonetheless, the main goal of treating hypoglycaemia is to immediately achieve and sustain euglycemia which can be achieved conservatively or definitively with surgery despite the etiology.</p> <p><strong>Keywords</strong>: Hepatocellular carcinoma, Hypoglycaemia, NICTH.</p>Audy Meutia ArianaGanjar Adityo PermadiHermawan Susanto
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2024-03-012024-03-0110151110.19184/ams.v10i1.45924 Intestinal Evisceration and Hemorrhagic Shock Due to Penetrating Abdominal Trauma in Elderly Patient at Rural Area
https://jurnal.unej.ac.id/index.php/JAMS/article/view/45271
<p>Penetrating trauma is the most frequent cause of death in patients aged 65 years and over. Penetrating trauma is often caused by armed violence, both firearms and sharp weapons, and occurs in urban civilian populations. In this case, penetrating trauma occurred in an elderly patient due to an abdominal stab wound caused by a palm sickle when harvesting palm fruit. The location of the incident was in a rural oil palm plantation area and far from the hospital. Limited facilities and resources at the community health center where the patient was first treated, resulted in initial treatment being less than optimal and inadequate. The penetrating abdominal trauma that occurred in this patient was accompanied by intestinal evisceration and hypovolemic shock which was an absolute indication for immediate laparotomy exploration. The patient's comorbidities in the form of chronic heart failure and the patient's elderly age need to be taken into consideration and attention to prevent initial and subsequent complications. After laparotomy, the patient was able to survive and recover well without any complications.</p> <p><strong>Keywords</strong>: Penetrating abdominal trauma, intestinal evisceration, laparotomy</p>Deny Dwi HartantoDony Ruswendro
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2024-03-012024-03-01101121610.19184/ams.v10i1.45271 Profiling and In Silico Study of Carica papaya Extract on Appetite Regulation
https://jurnal.unej.ac.id/index.php/JAMS/article/view/43095
<p><em>Carica papaya is one of the plants known to increase appetite. 15% papaya leaf solution can increase appetite, but if given in 20% solution there is a weight loss effect. Papaya leaves contain papain, carpaine and various other compounds. The mechanisms that affect appetite regulation involve ghrelin, leptin, ARC, IL-1β and NPY. This study aims to determine the compound profile contained in papaya leaf extract and its effect on appetite regulation that has been analyzed with in silico methods. The method of determining the profiling of papaya leaf extract compounds using UPLC / MS and analyzed using watermaslinx, in silico analysis used molecular docking methods using PatchDock. The results of this study are the most compounds found in papaya leaf extract (Carica papaya) is carpaine with a concentration of 50.33%. then, carpaine compounds will be analyzed using in silico method to see its effect on appetite regulation. The results of in silico analysis showed that carpaine has a strong potential to interact with NPY, IL-1 Beta, and Leptin, forming a stable complex. The strongest bond occurs between carpaine and leptin, so it can be predicted that papaya leaf extract, especially carpaine, causes a feeling of fullness.</em></p> <p><em><strong>Keywords</strong><em>: Carpaine; leptin, ghrelin, molecular docking, appetite</em></em></p>Isnaini IsnainiDwi SetyohadiWahyuni WahyuniRisma Yulfa RiyaniKhansa Khafiyya 'IbadurrahmanAndifa Anugerah Putra
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2024-03-012024-03-01101172410.19184/ams.v10i1.43095 Determinant Analysis of Carpal Tunnel Syndrome and Phalen’s Test Examination of Tobacco Sorting Workers at Jember District
https://jurnal.unej.ac.id/index.php/JAMS/article/view/43893
<p><em>Tobacco sorting officers in Jember Regency are still sorting tobacco leaves manually using hand muscles which can cause Musculo Skeletal Disorders (MSDs) complaints.One of the MSDs registered at the International Labor Organization (ILO) is Carpal Tunnel Syndrome (CTS) which is a disorder resulting from compression of the median nerve in the carpal tunnel at the wrist with the main symptom being tingling, pain radiating to the fingers which can be accompanied by numbness, weakness. muscles, stiffness, and possible muscle atrophy. This study aims to determine the factors associated with CTS supported by Phalen's test. This research is expected to provide information to workers and the public regarding health problems that can be experienced by tobacco sorting workers as well as being a consideration for increasing health insurance for these workers. This research was conducted using a cross-sectional survey design at PTPN A and PT B, Jember Regency with a sample calculation using the Slovin formula and obtained 246 respondents.The data analysis technique used was univariate SPSS analysis of frequency distribution, bivariate Chi Square analysis and SEM PLS multivariate analysis. research results show that education had an effect on the symptom severity scale, age had an influence on the symptom severity scale, age had an effect on the functional status scale and age had an influence on the Phalen's test. Conclusion:Age is the dominant factor affecting the symptom severity scale, functional status scale and Phalen's test.</em></p> <p><strong><em>Keywords</em></strong><em>: CTS (Carpal Tunnel Syndrome), BCTQ (Boston Carpal Tunnel Questionnaire), SSS (Symptom Severity Scale), FSS (Functional Status Scale), Phalen's Test</em></p>Paulina SamuelliaMei SyafriadiHairrudin Hairrudin
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2024-03-012024-03-01101253310.19184/ams.v10i1.43893 Analysis of Determinants of Tuberculosis in Stunted Toddlers in Rambipuji, Jember
https://jurnal.unej.ac.id/index.php/JAMS/article/view/46500
<p>Tuberculosis (TB) and stunting remain serious health problems in Indonesia. Stunting can impact a child's ability to resist infections, including TB. Stunted toddlers are more vulnerable to contracting TB compared to those with normal nutritional status. This research aims to explore the relationship and influence of TB risk factors on the occurrence of TB in stunted toddlers. This research is an analytical descriptive research with a cross sectional design. The research sample consisted of 183 stunted toddlers from eight villages in the Rambipuji sub-district, Jember. The research procedures included interviews, direct observations, and TB examinations in children. Interviews were conducted with the parents/guardians of the child respondents. Observations and direct measurements were performed to determine the physical characteristics of the respondents' living environments, including household density, ventilation area, natural lighting, humidity, and room temperature. The diagnosis of TB in children was established based on a scoring table for childhood TB. From the research findings, 15 children tested positive for TB (8.2%). Bivariate analysis showed a value of p <0.05 for nutritional status, close contact, household density, ventilation, and natural lighting factors. Multivariate analysis revealed significant results for close contact (p=0.000; OR=39.563), household density (p=0.015; OR=9.659), and nutritional status (p=0.029; OR=6.718) as risk factors. In conclusion, it can be inferred that the risk factors associated with TB occurrence in stunted toddlers include nutritional status, close contact history, household density, ventilation, and natural lighting. The factors influencing TB occurrence in stunted toddlers are close contact history, household density, and nutritional status.</p> <p><strong>Keywords</strong>: risk factor, stunted toddler, tuberculosis</p>Wiwien Sugih UtamiYunita ArmiyantiAdinda Putri Yusri Amrina
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2024-03-012024-03-01101344010.19184/ams.v10i1.46500 Effect of Andaliman Fruit Extract (Zanthoxylum acanthopodium DC.) on The Liver of Tartrazine Induced Rat (Rattus norvegicus L.)
https://jurnal.unej.ac.id/index.php/JAMS/article/view/39415
<p><em>Effect of tartrazine as synthetic food coloring that is consumed for long time has a toxic effect by free radicals in large quantities creating an imbalance in body and triggering disturbances, namely liver function. Free radicals can be minimized with antioxidants so they can reduce free radicals in body. Antioxidants can be found in all types of plants, one of which is Andaliman fruit. The purpose of this study was to determine effect ethanol extract of Andaliman fruit on SGOT-SGPT levels and histology of tartrazine-induced white rats. The research design used 25 white rats with 5 treatments and 5 replications for 30 days. Negative control group induced by 1% CMC, positive control induced by tartrazine 15 mg/kg BW, treatment groups 1, 2, 3 induced by tartrazine 15 mg/kg BW and ethanol extract andaliman fruit 150 mg/kg BW, 300 mg/kg BW, and 450 mg/kg BW. The stages in this study were screening for phytochemicals, total flavonoids and antioxidant activity as well as measurement of SGOT-SGPT levels and observation of liver histology. Data were analyzed using one way Anova and Duncan's further test. Results showed that phytochemical screening of Andaliman fruit extract contained flavonoids, terpenoids, </em><em>steroids and tannins. Total flavonoid content in extract was 7.8163 mgQE/g extract. And level antioxidant activity in the extract has an IC50 value of 102.35 ppm. The results of this study also showed that the extract had an effect on decreasing levels of SGOT-SGPT and could minimize liver histological damage after being induced by tartrazine</em><em>.</em></p> <p><strong><em>Keywords</em></strong><em>: </em><em>Andaliman, tartrazine, SGOT-SGPT, liver histology</em></p>Juandi AlGani SikaHusnarika FebrianiSyukriah Syukriah
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2024-03-012024-03-01101414710.19184/ams.v10i1.39415The Correlation between Thrombocyte, Hematocrit, and Leukocyte Count with Length of Hospitalization in Pediatric Patient with Dengue Hemorrhagic Fever (DHF)
https://jurnal.unej.ac.id/index.php/JAMS/article/view/40074
<p><em>Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus with mosquito vectors. Supporting examinations to determine the course of DHF include platelet counts, hematocrit values, and leukocyte counts. Length of hospitalization is the number of days when the patient receives treatment in the hospital, calculated when recorded as an inpatient until discharge from the hospital. This type of research is an analytic observational study with a cross sectional research design. Cases of pediatric DHF at Bina Sehat Hospital Jember for the period 2020-2022 totaled 296 patients. Data were obtained using medical records. Of the 296 cases of pediatric DHF, samples were then taken by purposive sampling according to the researcher's criteria until 44 samples were obtained. The data were then analyzed using Rank Spearman. The results of the data analysis showed that there was a strong opposite relationship (p = 0.000; r = -0.562) between platelet count and length of hospitalization, a strong unidirectional relationship (p = 0.001; r = 0.495) between hematocrit value and length of hospitalization, and a strong opposite relationship (p = 0.005; r = -0.415) between leukocyte count and length of hospitalization. Suggestions for future research are to use other variables such as nutritional status, medical history, and other laboratory examinations.</em></p> <p><em><strong>Keywords</strong>: Dengue Hemorrhagic Fever; Length of Hospitalization; Thrombocyte; Hematocrit; Leukocyte</em></p>Muhammad FikriMuhammad Ali ShodikinDwita Aryadina Rachmawati
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2024-03-012024-03-01101485210.19184/ams.v10i1.40074 Anti-lipase Activity of Kemuning (Murraya paniculata) Leaves Extract and Its Fractions
https://jurnal.unej.ac.id/index.php/JAMS/article/view/44240
<p><em>Kemuning (Murraya paniculata) belongs to the Rutaceae family, it grows a lot in tropical areas such as Indonesia. Traditionally, Kemuning leaves are used for weight loss preparations and are believed to contain compounds that can inhibit pancreatic lipase, including flavonoids. This study aimed to reveal the antilipase activity of Kemuning leaves extract and its fractions. The extraction of Kemuning leaves was carried out by maceration with 70% ethanol as solvent. The vacuum liquid chromatography method was used to separate the secondary metabolites in the extract with the stationary phase of silica gel and the eluent mixture of n-hexane, ethyl acetate, and methanol in a gradient manner. Meanwhile, the antilipase activity was tested by colorimetric method, with p-nitrophenyl butyrate as a substrate and orlistat as a positive control. The extract obtained was 19.94% of the weight of the simplicia. The separated extract was collected in 20 flasks and then combined based on the Rf value of the spots observed on thin layer chromatography (TLC) producing 8 fractions (fractions A-H). The percentage yields of fractions A-H were 1.20, 1.33, 1.80, 3.92, 3.57, 4.20, 16.85, and 14.47%, respectively. Antilipase activity was indicated by IC<sub>50</sub> values, which were 17.603 ± 1.660 and 108.554 ± 1.660 µg/mL for orlistat and extract, respectively. The antilipase activities of fractions A-H were 130.19 ± 2.90, 119.52 ± 1.95, 96.95 ± 1.81, 91.65 ± 0.78, 95.30 ± 1.46, 114.76 ± 2.87, 127.07 ± 3.56, and 134,04 ± 3.16 µg/mL, respectively. Based on these results, it can be concluded that the extract and its fractions exhibit very strong antilipase activity.</em></p> <p><strong><em>Keywords</em></strong><em>: </em><em>Murraya paniculata; extract; fraction; antilipase</em></p>Nuri NuriTazkiyatul FitriyahEndah PuspitasariBawon TriatmokoDewi Dianasari
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2024-03-012024-03-01101535810.19184/ams.v10i1.44240 Correlation between Zinc Intake and Height of Children Aged 6-59 Months in Jelbuk and Sumberjambe Districts
https://jurnal.unej.ac.id/index.php/JAMS/article/view/42448
<p><em>Stunting is a nutritional problem that people around the world are facing. The World Health Organization (WHO) has determined Indonesia as one of the five stunting prevalence subregions in the Southeast Asia region. Zinc includes micro-nutrients that are important for the growth and development of children. The prevalence of zinc deficiency in children in Indonesia in 2006 was 36.1%. This study aims to determine the relationship between zinc intake and the length/height of children aged 6-59 months in the Districts of Jelbuk and Sumberjambe. This research is an analytic observational study with a cross-sectional design. The sample used was 119, derived from secondary data from previous studies. Zinc intake in children was obtained through 24-hour food recall data and then analyzed using nutrisurvey software, while body length/height is the maximum distance from the vertex to the soles of the feet. The study results were that 57.2% of the samples had insufficient zinc intake, with an average daily intake of 4.37 ± 2.35 mg, and as many as 60.5% had TB below normal. The data analysis showed a significant relationship between zinc intake and the length/height of children aged 6-59 months (p=0.001), with a reasonably strong relationship (r=0.295). This study concludes that there is a relationship between zinc intake and the length/height of children aged 6-59 months in the Jelbuk and Sumberjambe Districts.</em></p> <p><em><strong>Keywords</strong><em>: Zinc, Stunted, Stunting</em></em></p>Eling NurdiantiHairrudin HairrudinDwita Aryadina RachmawatiAncah Caesarina Novi Marchianti
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