Increased of IL-4 and Ig E Level in Infection Hookworm in Plantation Workers in Jember
Abstract
Hookworm infection is a disease that is included in the neglected tropical disease. Hookworm infection is suffered by many plantation workers who are closely related to the soil in daily life. Immune response in hookworm-infected individuals will experience disorders, especially in eosinophilia, mastocytosis, and IgE stimulation. It is therefore important to know the immune response to hookworm infections in plantation workers. In this study, eosinophilia was calculated on peripheral blood smears and counts of IL-4 and Ig-E levels by ELISA. The results showed an increase in eosinophil levels from blood samples of patients and a significant increase in IL-4 and IgE levels based on the results of statistical analysis.
Keywords: hookworm, plantation worker, IL-4, and IgE
References
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Daniłowicz-Luebert, E., O’Regan, N. L., Steinfelder, S., & Hartmann, S. (2011). Modulation of specific and allergy-related immune responses by helminths. Journal of Biomedicine and Biotechnology, 2011. https://doi.org/10.1155/2011/821578
Gaze, S., Bethony, J. M., & Periago, M. V. (2014). Immunology of experimental and natural human hookworm infection. Parasite Immunology, 36(8), 358–366. https://doi.org/10.1111/pim.12088
Gazzinelli-Guimaraes, P. H., & Nutman, T. B. (2018). Helminth Parasites and Immune Regulation. F1000Res. 2018;7:F1000 Faculty Rev-1685. https://doi.org/doi: 10.12688/f1000research.15596.1
Girgis, N. M., Gundra, U. M., & Loke, P. (2013). Immune Regulation during Helminth Infections. PLOS Pathogens, 9(4), e1003250. https://doi.org/10.1371/JOURNAL.PPAT.1003250
Guo, A. ye, Lin, X. meng, Zhang, Y. qin, & Wu, H. (2015). The Levels of IL-4, IL-9, and IgE in Patients Infected with Intestinal Helminths and their Clinical Values. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases, 33(2), 110–113.
Hotez, P. J., Brindley, P. J., Bethony, J. M., King, C. H., Pearce, E. J., & Jacobson, J. (2008). Helminth infections: the great neglected tropical diseases. The Journal of Clinical Investigation, 118(4), 1311–1321. https://doi.org/10.1172/JCI34261
Loukas, A., Hotez, P. J., Diemert, D., Yazdanbakhsh, M., McCarthy, J. S., Correa-Oliveira, R., Croese, J., & Bethony, J. M. (2016). Hookworm infection. Nature Reviews Disease Primers 2016 2:1, 2(1), 1–18. https://doi.org/10.1038/nrdp.2016.88
McSorley, H. J., & Loukas, A. (2010). The Immunology of Human Hookworm Infections. Parasite Immunology, 32(8), 549–559. https://doi.org/10.1111/j.1365-3024.2010.01224.x
Nair, M. G., & Herbert, D. R. (2016). Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages. Immunology, 148(2), 115–124. https://doi.org/10.1111/imm.12601
Primadana, A., Nurdian, Y., Agustina, D., Hermansyah, B., & Armiyanti, Y. (2019). EOSINOPHILIA AS A PREDICTOR MORBIDITY OF SOIL- TRANSMITTED HELMINTHIASES AMONG WIDODAREN PLANTATION WORKERS IN JEMBER. Journal of Vocational Health Studies, 3(2), 47–52. https://doi.org/10.20473/jvhs.V3.I2.2019.47-52
Rusjdi, S. R. (2015). RESPON Th2 PADA INFEKSI CACING USUS. Majalah Kedokteran Andalas, 33(2). https://doi.org/10.22338/MKA.V33.I2.P%P.2009
Rusmartini, T., Natadisastra, D., & Sundusi, D. (2014). Parasitologi Kedokteran. Ditinjau Dari Organ Tubuh Yang Diserang (D. Natadisastra & R. Agoes (eds.)). Buku Kedokteran EGC.
Schneider, B., Jariwala, A. R., Periago, M. V., Gazzinelli, M. F., Bose, S. N., Hotez, P. J., Diemert, D. J., & Bethony, J. M. (2011). A history of hookworm vaccine development. Human Vaccines, 7(11), 1234–1244. https://doi.org/10.4161/HV.7.11.18443
Supali, T., Margono, S. ., & Abidin, S. A. . (2017). Nematoda Usus. In Keempat (Ed.), Buku Ajar Parasitologi Kedokteran. Fakultas Kedokteran Universitas Jember.
Tapiheru, M. J. R., & Zain, N. (2021). PREVALENSI INFEKSI SOIL TRANSMITTED HELMINTH PADA MURID SEKOLAH DASAR NEGERI 105296 KECAMATAN PERCUT SEI TUAN, KABUPATEN DELI SERDANG, SUMATERA UTARA. JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 8(3), 1–7. https://doi.org/10.53366/JIMKI.V8I3.249
Walana, W., Aidoo, E. N. K., & Tay, S. C. K. (2014). Prevalence of hookworm infection: a retrospective study in Kumasi. Asian Pacific Journal of Tropical Biomedicine, 4(Suppl 1), S158–S161. https://doi.org/10.12980/APJTB.4.2014APJTB-2013-0014
Published
2023-02-28
How to Cite
HERMANSYAH, Bagus; ARMIYANTI, Yunita; UTAMI, Wiwien Sugih.
Increased of IL-4 and Ig E Level in Infection Hookworm in Plantation Workers in Jember.
Journal of Agromedicine and Medical Sciences, [S.l.], v. 9, n. 1, p. 27-30, feb. 2023.
ISSN 2714-5654.
Available at: <https://jurnal.unej.ac.id/index.php/JAMS/article/view/37301>. Date accessed: 22 nov. 2024.
doi: https://doi.org/10.19184/ams.v9i1.37301.
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Section
Original Research Articles
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