Symptoms Improvement of Cerebral Venous Sinus Thrombosis: A Case Report

  • Komang Yunita Wiryaning Putri Department of Neurology, Soebandi Regional Hospital, Jember, Indonesia; Faculty of Medicine, University of Jember, Jember, Indonesia
  • Novan Krisno Adji Department of Neurosurgery, Soebandi Regional Hospital, Jember, Indonesia; Faculty of Medicine, University of Jember, Jember, Indonesia
  • Azham Purwandhono Department of Neurology, Soebandi Regional Hospital, Jember, Indonesia; Faculty of Medicine, University of Jember, Jember, Indonesia http://orcid.org/0000-0002-2303-5455
  • Muhammad Yudha Nugraha Faculty of Medicine, University of Jember, Jember, Indonesia http://orcid.org/0000-0003-4330-6643
  • Salsabila Maula Zalfa El Hamzah Faculty of Medicine, University of Jember, Jember, Indonesia http://orcid.org/0000-0003-2965-8319

Abstract

Cerebral venous sinus thrombosis (CVT) is a rare cause of stroke, a life-threatening disorder that occurs in approximately 0,5-1% of all stroke incidents. Various clinical presentations, risk factors, and neuroimaging findings of this disease may cause a delay in the early diagnosis and treatment of CVT. We discuss a case of a 34-year-old female who was admitted to the emergency room (ER) with the onset of a generalized tonic-clonic seizure with a progressive headache in the occipitotemporal region. Based on head CT, there was multiple hyperdense and cerebral venous infarction in the posterior left parietal lobe. D-dimer evaluation, there was an increasing level of D-dimer (>10.000 ng/mL). The patient was treated with the primary therapy heparin. After 15 days of being hospitalized, the patient was discharged without any sequelae.


Keywords: CVT, heparin, stroke

References

Behrouzi, R., & Punter, M. (2018). Diagnosis and management of cerebral venous thrombosis. Clinical Medicine (London, England), 18(1), 75–79. https://doi.org/10.7861/clinmedicine.18-1-75

Bose, G., Graveline, J., Yogendrakumar, V., Shorr, R., Fergusson, D. A., Le Gal, G., … Dowlatshahi, D. (2021). Direct oral anticoagulants in treatment of cerebral venous thrombosis: a systematic review. BMJ Open, 11(2), e040212. https://doi.org/10.1136/bmjopen-2020-040212

Bousser, M.-G., & Crassard, I. (2012). Cerebral venous thrombosis, pregnancy and oral contraceptives. Thrombosis Research, 130 Suppl 1, S19-22. https://doi.org/10.1016/j.thromres.2012.08.264

Cavalcanti, D. D., Raz, E., Shapiro, M., Dehkharghani, S., Yaghi, S., Lillemoe, K., … Nelson, P. K. (2020). Cerebral Venous Thrombosis Associated with COVID-19. AJNR. American Journal of Neuroradiology, 41(8), 1370–1376. https://doi.org/10.3174/ajnr.A6644

Conrad, J., Pawlowski, M., Dogan, M., Kovac, S., Ritter, M. A., & Evers, S. (2013). Seizures after cerebrovascular events: risk factors and clinical features. Seizure, 22(4), 275–282. https://doi.org/10.1016/j.seizure.2013.01.014

Coutinho, J M. (2015). Cerebral venous thrombosis. Journal of Thrombosis and Haemostasis : JTH, 13 Suppl 1, S238-44. https://doi.org/10.1111/jth.12945

Coutinho, Jonathan M, Zuurbier, S. M., Aramideh, M., & Stam, J. (2012). The incidence of cerebral venous thrombosis: a cross-sectional study. Stroke, 43(12), 3375–3377. https://doi.org/10.1161/STROKEAHA.112.671453

Ferro, J. M., Bousser, M.-G., Canhão, P., Coutinho, J. M., Crassard, I., Dentali, F., … Stam, J. (2017). European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology. European Journal of Neurology, 24(10), 1203–1213. https://doi.org/10.1111/ene.13381

Hiltunen, S., Putaala, J., Haapaniemi, E., & Tatlisumak, T. (2016). Long-term outcome after cerebral venous thrombosis: analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients. Journal of Neurology, 263(3), 477–484. https://doi.org/10.1007/s00415-015-7996-9

Kalita, J., Chandra, S., & Misra, U. K. (2012). Significance of seizure in cerebral venous sinus thrombosis. Seizure, 21(8), 639–642. https://doi.org/10.1016/j.seizure.2012.07.005

Luo, Y., Tian, X., & Wang, X. (2018). Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review. Frontiers in Aging Neuroscience, 10. https://doi.org/10.3389/fnagi.2018.00002

Mackman, N. (2012). New insights into the mechanisms of venous thrombosis. The Journal of Clinical Investigation, 122(7), 2331–2336. https://doi.org/10.1172/JCI60229

Mahale, R., Mehta, A., John, A. A., Buddaraju, K., Shankar, A. K., Javali, M., & Srinivasa, R. (2016). Acute seizures in cerebral venous sinus thrombosis: What predicts it? Epilepsy Research, 123, 1–5. https://doi.org/10.1016/j.eplepsyres.2016.01.011

Meng, R., Wang, X., Hussain, M., Dornbos, D. 3rd, Meng, L., Liu, Y., … Ji, X. (2014). Evaluation of plasma D-dimer plus fibrinogen in predicting acute CVST. International Journal of Stroke : Official Journal of the International Stroke Society, 9(2), 166–173. https://doi.org/10.1111/ijs.12034

Misra, U. K., Kalita, J., Chandra, S., Kumar, B., & Bansal, V. (2012). Low molecular weight heparin versus unfractionated heparin in cerebral venous sinus thrombosis: a randomized controlled trial. European Journal of Neurology, 19(7), 1030–1036. https://doi.org/10.1111/j.1468-1331.2012.03690.x

Ulivi, L., Squitieri, M., Cohen, H., Cowley, P., & Werring, D. J. (2020). Cerebral venous thrombosis: a practical guide. Practical Neurology, 20(5), 356 LP – 367. https://doi.org/10.1136/practneurol-2019-002415

Wasay, M., Khan, M., Rajput, H. M., Farooq, S., Memon, M. I., AlRukn, S. A., … Awan, S. (2019). New Oral Anticoagulants versus Warfarin for Cerebral Venous Thrombosis: A Multi-Center, Observational Study. Journal of Stroke, 21(2), 220–223. https://doi.org/10.5853/jos.2019.00150
Published
2022-06-24
How to Cite
WIRYANING PUTRI, Komang Yunita et al. Symptoms Improvement of Cerebral Venous Sinus Thrombosis: A Case Report. Journal of Agromedicine and Medical Sciences, [S.l.], v. 8, n. 2, p. 68-71, june 2022. ISSN 2714-5654. Available at: <https://jurnal.unej.ac.id/index.php/JAMS/article/view/30193>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.19184/ams.v8i2.30193.
Section
Case Report Article