Wound Healing Activity of Galam Flower (Melaleuca Cajuputi Subsp. Cumingiana (Turcz.) Barlow) Methanol Extract Wistar Rats

  • Kartika veranisa putri Students of the Medical Study Program Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, Indonesia
  • Ika Novitasari Students of the Medical Study Program Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, Indonesia
  • Hilma Wardatina Students of the Medical Study Program Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, Indonesia
  • Lilis Tangkeallo Students of the Medical Study Program Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, Indonesia
  • Muhammad Dawud Ashari Students of the Medical Study Program Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, Indonesia
  • Isnaini - Isnaini Department of Pharmacology, Medical Study Program Undergraduate Program, Faculty of Medicine, ULM Banjarmasin, Indonesia

Abstract

Wound is an incontinence condition of skin or mucosal epithelial tissue due to physical or thermal damage. One of the plants that has the potential as a wound healer is gelam (Melaleuca sp). Gelam flower methanol extract has antibacterial activity with a minimum inhibitory level of 1.7 mg/mL. This study aimed to analyze the wound healing activity of gelam flower methanol extract (Melaleuca sp.) in Wistar strain rats that were initiated by the wound seen from the histology of the rat skin. This research uses posttest only method with control group design. Thirty male wistar rats were divided into five groups consisting of a positive control group, a negative control group, 1% gelam flower extract gel, 2% gelam flower extract gel, and 4% gelam flower extract gel. Based on histological data, the positive control treatment group and 4% gel treatment group gave the same results. Both indicate that the skin tissue has begun to connect. The conclusions the three gelam flower methanol extract gel formulas showed wound healing activity and the 4% gelam flower methanol extract gel (Melaleuca Sp.) gave the greatest wound healing activity.


Keyword: Melaleuca sp, antibacterial activity, wound initiated healing

Published
2022-02-28
How to Cite
PUTRI, Kartika veranisa et al. Wound Healing Activity of Galam Flower (Melaleuca Cajuputi Subsp. Cumingiana (Turcz.) Barlow) Methanol Extract Wistar Rats. Journal of Agromedicine and Medical Sciences, [S.l.], v. 8, n. 1, p. 34-38, feb. 2022. ISSN 2714-5654. Available at: <https://jurnal.unej.ac.id/index.php/JAMS/article/view/27451>. Date accessed: 19 sep. 2024. doi: https://doi.org/10.19184/ams.v8i1.27451.
Section
Original Research Articles