Antibacterial and Antifungal Activity of Galam (Melaleuca cajuputi subsp. Cumingiana (Turcz.) Barlow) Extract against E. coli bacteria and C. albicans fungi

  • Isnaini Isnaini Department of Pharmacology and Therapy, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia
  • Agung Biworo Department of Pharmacology and Therapy, Faculty of Medicine, Lambung Mngkurat University, Banjarmasin, Indonesia
  • Husnul Khatimah Department of Biomedical Science, Faculty of Medicine, Lambung Mangkurat university, Banjarmasin, Indonesia
  • Khusnan Mustofa Gufron Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia
  • Shafa Rahmani Puteri Undergraduate Student Program, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia

Abstract

Galam (Melaleuca cajuputi subsp. Cumingiana (Turcz.) Barlow) is a peat swamp forest plant. This plant is used to treat respiratory diseases, colitis, sore throat, itchy skin, diarrhea, and dizziness. This study aimed to analyze the antibacterial and antifungal activity of the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow flowers and fruit against Escherichia coli and Candida albicans bacteria. This research is a pretest-posttest research with control group design and consists of 3 stages of research. The first stage is the phytochemical screening test, the second stage determines the minimum inhibitory concentration (MIC) and the third determines the minimum bactericidal concentration (MBC). The results showed that the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow flowers and fruit contained terpenoids, flavonoids, phenols, saponins, quinones, steroids, tannins, while alkaloid compounds only found in the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow fruit. The MIC and MBC values ​​of M. cajuputi subsp. Cumingiana (Turcz.) Barlow flower methanol extract against E. coli were 1.67 and 2.083 mg/mL, respectively, while the MIC and MBC values ​​of the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow flower against C. albicans were 3.125 and 25 mg/mL. The MIC and MBC values ​​of the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow fruit against E. coli have same value  were 3.334 mg/mL, while the MIC and MBC values ​​of the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow fruit against C. albicans were 3.125 and 12.5 mg/mL, respectively.


Keywords: Galam  antibacterial, antifungal, Escherichia coli, Candida albicans

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Published
2021-06-28
How to Cite
ISNAINI, Isnaini et al. Antibacterial and Antifungal Activity of Galam (Melaleuca cajuputi subsp. Cumingiana (Turcz.) Barlow) Extract against E. coli bacteria and C. albicans fungi. Journal of Agromedicine and Medical Sciences, [S.l.], v. 7, n. 2, p. 79-83, june 2021. ISSN 2714-5654. Available at: <https://jurnal.unej.ac.id/index.php/JAMS/article/view/23467>. Date accessed: 05 dec. 2021. doi: https://doi.org/10.19184/ams.v7i2.23467.
Section
Original Research Articles