Effect Of Antiseptic on Male Mice (Mus musculus L.) Body Weight
Abstract
The safety of using liquid soap to wash fruit or vegetables is unclear. The purpose of this study was to determine the effect of liquid soap on the body weight of mice (Mus musculus). This research is pure experimental using a completely randomized design. The treatment given was soaking fruits and vegetables in liquid soap with a concentration of 20 mL/L for 30 and 60 seconds, each treatment had 10 replications. The mice used were male, aged 4 weeks, with a total of 30 mice selected by cluster random sampling. Fruit and vegetable extracts were administered once daily, alternating fruit and vegetable extracts for 8 weeks in addition to the main food. Mice’s body weight was measured using a digital scale. The data were analyzed using One Way Anova and Duncan's advanced test. The results showed that liquid soap had a significant effect on the body weight of mice, but the average body weight of fruits and vegetables soaked in liquid soap for 30 seconds and 60 seconds was not significantly different. The conclusion of this study supports other research that the use of liquid soap containing surfactants for a long time continuously has a negative effect on body weight.
References
Ardiani. (2020). Perbandingan Kenaikan Berat Badan Pada Akseptor KB Suntik 1 Bulan Dan Suntik 3 Bulan Pada Periode (Januari-September 2019) Di Bidang Praktek Mandiri F.Sri Retnaningtyas Kecamatan Tambaksari Surabaya. Universitas Muhammadiyah Surabaya.
Arora, Jayati. Anuj Ranjan. Abhishek Chauhan. Rima Biswas.|Vishnu D. Rajput. Svetlana Sushkova. Saglara Mandzhieva. Tatiana Minkina. Tanu Jindal. (2022). Surfactant pollution, an emerging threat to ecosystem : Approaches for effective bacterial degradation. Journal of Applied Microbiology. 133:1229–1244.
Badmus, Suaibu O. Hussein K. Amusa, Tajudeen A. Oyehan, Tawfik A Saleh. (2021). Environmental risks and toxicity of surfactants: overview of analysis, assessment, and remediation techniques. Environmental Science and Pollution Research. 28:62085–62104
Bondi, C. A. M., Marks, J. L., Wroblewski, L. B., Raatikainen, H. S., Lenox, S. R., & Gebhardt, K. E. (2015). Human and Environmental Toxicity of Sodium Lauryl Sulfate ( SLS ): Evidence for Safe Use in Household Cleaning Products. 27–32. https://doi.org/10.4137/EHI.S31765
Bradai, M., Han, J., El, A., Funamizu, N., Sayadi, S., & Isoda, H. (2016). Effect of linear alkylbenzene sulfonate ( LAS ) on human intestinal Caco-2 cells at non cytotoxic concentrations. Cytotechnology, 68(4), 1275–1283. https://doi.org/10.1007/s10616-015-9887-4
Chen, Chung-Min. Hsiu-Chu Chou, Willie Lin and Chris Tseng. (2017). Surfactant effects on the viability and
function of human mesenchymal stem cells: in vitro and in vivo assessment. Stem Cell Research & Therapy.8: 180
Dewi, L. A. P. (2006). Pembuataan Gel Ekstrak Daun Pepaya Dengan Variasi Penambahan Hydroxypropyl Methyl Cellulose. Politeknik Sriwijaya Palembang.
Fikri. (2018). Uji Toksisitas Lc50 (Lethal Concentration) Surfaktan LAS (Linear AlkilBenzene Sulfonate) Dan Analisis Histologi Terhadap Benih Ikan Kakap Merah (Lutjanus sp) Pada Skala Laboratorium (Vol. 50). Universitas Sriwijaya.
Gargi, R., Pimpliskar, M. R., Vanmali, H. S., & Jadhav, R. N. (2017). Efficacy study of some antiseptics and disinfectants. Int. J. of Life Sciences, 5(4), 593–598. https://doi.org/10.13140/RG.2.2.13897.44640
Hardini, D. C., Dhahiyat, Y., Fakultas, M., Kelautan, I., Pengajar, S., Perikanan, F., & Unpad, K. (2012). Pengaruh Konsentrasi Pemaparan Surfaktan Alkyl Benzene Sulfonate Terhadap Toksisitas Dan Kerusakan Jaringan Ikan Nila. Jurnal Perikanan Dan Kelautan, 3(1), 59–63.
Husain, A., Tendean, L., & Queljoe, E. De. (2015). Pengaruh Kelebihan Berat Badan / Overweight Terhadap Terjadinya Disfungsi Seksual Pria. Jurnal E-Biomedik, 3(1999). https://doi.org/10.35790/ebm.v3i3.10143
Indonesia, P. P. (2001). Peraturan Pemerintah Republik Indonesia Nomor 82 Tahun 2001. https://peraturan.bpk.go.id/
Kamiswari, R., Hidayat, M.T., dan Rahayu, Y. S. (2013). Pengaruh Pemberian Deterjen terhadap Mortalitas Ikan Platy sp. Berkala Ilmia Biologi, 2(1), 139–142.
Megasari Titian, A. A. (2011). Hubungan Tingkat Pengetahuan Penjamah Makanan Dengan Keamanan Pangan Pada Warung Lawar Babi Di Kawasan Pariwisata Kuta Kabupaten Badung Provinsi Bali. Politeknik Kesehatan Denpasar.
Nair, A., & Jacob, S. (2016). A simple practice guide for dose conversion between animals and human. Journal of Basic and Clinical Pharmacy, 7(2), 27. https://doi.org/10.4103/0976-0105.177703
Organization, W. H. (2009). WHO Guidelines on Hand Hygiene in Health Care First.
Purbosari, I. (2021). Uji Aktivitas Daya Hambat Antimikroba Produk Antiseptik Hand Sanitizer dan Sabun Cair terhadap Bakteri Staphylococcus aureus. Jurnal Sains Farmasi, 2(1), 38–43.
Putri, P. D. D ;Gusdini, N.; Febrina, L. (2022). Dampak Peningkatan Penggunaan Sabun Antiseptik Terhadap Mikroorganisme Di Aliran Anak Sungai Ciliwung. Universitas Sahid.
Rachmi, Z. (2020). Efek toksisitas deterjen dan pestisida terhadap pertumbuhan ikan nila (Oreochomis niloticus). Jurnal Faperta Uniki, 1(1), 28–34.
Septiani, I. (2019). Pengaruh Beda Konsentrasi Terhadap Filtrasi Nira Menggunakan Plate and Frame Filter Press. Universitas Diponegoro Semarang.
Sharfina, F., Sani, R. P., Farma, S. A., & Advinda, L. (2021). Antibacterial Activity Test Antiseptic Soap Against Staphylococcus aureus Uji Aktivitas Antibakteri Sabun Antiseptik Terhadap Staphylococcus aureus. 1, 717–724. https://doi.org/10.24036/prosemnasbio/vol1/94
Solikhah, T., Studi, P., Biologi, P., Dahlan, U. A., Iii, K., & Soepomo, J. P. (2015). Pengaruh Surfaktan terhadap Pertumbuhan dan Histopatologi Insang Ikan Nila ( Oreochromis Niloticus ) sebagai Materi Pembelajaran Siswa SMA Kelas X. 2(1), 248–255.
Suparjo, M. N. (2009). Kerusakan Jaringan Insang Ikan Nila ( Oreochromis niloticus L ) akibat deterjen Detergent to Mortality Level and Structural Damage of Gill Tissues on Nila Fish. Jurnal Saintek Perikanan, 5(2), 1–7. https://doi.org/10.14710/ijfst.5.2.1-7
Trevisani, M., Fedrizzi, G., & Diegoli, G. (2019). Chemical hazards in meat and associated monitoring activities. 7, 315–340. https://doi.org/10.3920/978-90-8686-877-3_13
Ujiani, S., & Tuntun, M. (2019). Kemampuan Sabun Antiseptik Cair yang Mengandung Triclosan yang Terdaftar di BPOM dalam Menghambat Pertumbuhan Bakteri Escherichia coli. 10(April), 17–24.
Wang, Y., Zhang, Y., Li, X., Sun, M., Wei, Z., Wang, Y., & Gao, A. (2015). Exploring the Effects of Different Types of Surfactants on Zebrafish Embryos and Larvae. Nature Publishing Group, 1–10. https://doi.org/10.1038/srep10107
Wastiti, T. W., Muryani, S., & Werdiningsih, I. (2017). Pemanfaatan ekstrak bawang putih (Allium sativum L.) Sebagai disinfektan untuk menurunkan angka kuman dinding di ruang laboratorium. Sanitasi: Jurnal Kesehatan Lingkungan, 8(4), 175. https://doi.org/10.29238/sanitasi.v8i4.67
Widyastuti, A., N. (2019). Uji aktivitas antibakteri berbagai konsentrasi ekstrak etanol daun kersen (Muntingia calabura L.) Terhadap pertumbuhan bakteri Klebsiella pneumoniae SECARA IN VITRO. Politeknik Kesehatan Kemenkes Denpasar.
Yuan, C. L., Xu, Z. Z., Fan, M. X., Liu, H. Y., Xie, Y. H., & Zhu, T. (2014). Study on characteristics and harm of surfactants. 6(7), 2233–2237.
Yulianti, I., Elies, M., dan Faisal, I. (2018). Hubungan Perilaku Sedentari Dengan Kejadian Obesitas Pada Remaja Di Smp Negeri 1 Mojoanyar Mojokerto Indra. Jurnal Surya, 10(1), 1–5.
Zheng, Minyi. Lingyun Mo, Ruqiong Qin, Liying Liang and Fan Zhang (2017). Research Progress of Surfactant. AIP Conference Proceedings. AIP Publishing 1794, 030008. https://doi.org/10.1063/1.4971930
Arora, Jayati. Anuj Ranjan. Abhishek Chauhan. Rima Biswas.|Vishnu D. Rajput. Svetlana Sushkova. Saglara Mandzhieva. Tatiana Minkina. Tanu Jindal. (2022). Surfactant pollution, an emerging threat to ecosystem : Approaches for effective bacterial degradation. Journal of Applied Microbiology. 133:1229–1244.
Badmus, Suaibu O. Hussein K. Amusa, Tajudeen A. Oyehan, Tawfik A Saleh. (2021). Environmental risks and toxicity of surfactants: overview of analysis, assessment, and remediation techniques. Environmental Science and Pollution Research. 28:62085–62104
Bondi, C. A. M., Marks, J. L., Wroblewski, L. B., Raatikainen, H. S., Lenox, S. R., & Gebhardt, K. E. (2015). Human and Environmental Toxicity of Sodium Lauryl Sulfate ( SLS ): Evidence for Safe Use in Household Cleaning Products. 27–32. https://doi.org/10.4137/EHI.S31765
Bradai, M., Han, J., El, A., Funamizu, N., Sayadi, S., & Isoda, H. (2016). Effect of linear alkylbenzene sulfonate ( LAS ) on human intestinal Caco-2 cells at non cytotoxic concentrations. Cytotechnology, 68(4), 1275–1283. https://doi.org/10.1007/s10616-015-9887-4
Chen, Chung-Min. Hsiu-Chu Chou, Willie Lin and Chris Tseng. (2017). Surfactant effects on the viability and
function of human mesenchymal stem cells: in vitro and in vivo assessment. Stem Cell Research & Therapy.8: 180
Dewi, L. A. P. (2006). Pembuataan Gel Ekstrak Daun Pepaya Dengan Variasi Penambahan Hydroxypropyl Methyl Cellulose. Politeknik Sriwijaya Palembang.
Fikri. (2018). Uji Toksisitas Lc50 (Lethal Concentration) Surfaktan LAS (Linear AlkilBenzene Sulfonate) Dan Analisis Histologi Terhadap Benih Ikan Kakap Merah (Lutjanus sp) Pada Skala Laboratorium (Vol. 50). Universitas Sriwijaya.
Gargi, R., Pimpliskar, M. R., Vanmali, H. S., & Jadhav, R. N. (2017). Efficacy study of some antiseptics and disinfectants. Int. J. of Life Sciences, 5(4), 593–598. https://doi.org/10.13140/RG.2.2.13897.44640
Hardini, D. C., Dhahiyat, Y., Fakultas, M., Kelautan, I., Pengajar, S., Perikanan, F., & Unpad, K. (2012). Pengaruh Konsentrasi Pemaparan Surfaktan Alkyl Benzene Sulfonate Terhadap Toksisitas Dan Kerusakan Jaringan Ikan Nila. Jurnal Perikanan Dan Kelautan, 3(1), 59–63.
Husain, A., Tendean, L., & Queljoe, E. De. (2015). Pengaruh Kelebihan Berat Badan / Overweight Terhadap Terjadinya Disfungsi Seksual Pria. Jurnal E-Biomedik, 3(1999). https://doi.org/10.35790/ebm.v3i3.10143
Indonesia, P. P. (2001). Peraturan Pemerintah Republik Indonesia Nomor 82 Tahun 2001. https://peraturan.bpk.go.id/
Kamiswari, R., Hidayat, M.T., dan Rahayu, Y. S. (2013). Pengaruh Pemberian Deterjen terhadap Mortalitas Ikan Platy sp. Berkala Ilmia Biologi, 2(1), 139–142.
Megasari Titian, A. A. (2011). Hubungan Tingkat Pengetahuan Penjamah Makanan Dengan Keamanan Pangan Pada Warung Lawar Babi Di Kawasan Pariwisata Kuta Kabupaten Badung Provinsi Bali. Politeknik Kesehatan Denpasar.
Nair, A., & Jacob, S. (2016). A simple practice guide for dose conversion between animals and human. Journal of Basic and Clinical Pharmacy, 7(2), 27. https://doi.org/10.4103/0976-0105.177703
Organization, W. H. (2009). WHO Guidelines on Hand Hygiene in Health Care First.
Purbosari, I. (2021). Uji Aktivitas Daya Hambat Antimikroba Produk Antiseptik Hand Sanitizer dan Sabun Cair terhadap Bakteri Staphylococcus aureus. Jurnal Sains Farmasi, 2(1), 38–43.
Putri, P. D. D ;Gusdini, N.; Febrina, L. (2022). Dampak Peningkatan Penggunaan Sabun Antiseptik Terhadap Mikroorganisme Di Aliran Anak Sungai Ciliwung. Universitas Sahid.
Rachmi, Z. (2020). Efek toksisitas deterjen dan pestisida terhadap pertumbuhan ikan nila (Oreochomis niloticus). Jurnal Faperta Uniki, 1(1), 28–34.
Septiani, I. (2019). Pengaruh Beda Konsentrasi Terhadap Filtrasi Nira Menggunakan Plate and Frame Filter Press. Universitas Diponegoro Semarang.
Sharfina, F., Sani, R. P., Farma, S. A., & Advinda, L. (2021). Antibacterial Activity Test Antiseptic Soap Against Staphylococcus aureus Uji Aktivitas Antibakteri Sabun Antiseptik Terhadap Staphylococcus aureus. 1, 717–724. https://doi.org/10.24036/prosemnasbio/vol1/94
Solikhah, T., Studi, P., Biologi, P., Dahlan, U. A., Iii, K., & Soepomo, J. P. (2015). Pengaruh Surfaktan terhadap Pertumbuhan dan Histopatologi Insang Ikan Nila ( Oreochromis Niloticus ) sebagai Materi Pembelajaran Siswa SMA Kelas X. 2(1), 248–255.
Suparjo, M. N. (2009). Kerusakan Jaringan Insang Ikan Nila ( Oreochromis niloticus L ) akibat deterjen Detergent to Mortality Level and Structural Damage of Gill Tissues on Nila Fish. Jurnal Saintek Perikanan, 5(2), 1–7. https://doi.org/10.14710/ijfst.5.2.1-7
Trevisani, M., Fedrizzi, G., & Diegoli, G. (2019). Chemical hazards in meat and associated monitoring activities. 7, 315–340. https://doi.org/10.3920/978-90-8686-877-3_13
Ujiani, S., & Tuntun, M. (2019). Kemampuan Sabun Antiseptik Cair yang Mengandung Triclosan yang Terdaftar di BPOM dalam Menghambat Pertumbuhan Bakteri Escherichia coli. 10(April), 17–24.
Wang, Y., Zhang, Y., Li, X., Sun, M., Wei, Z., Wang, Y., & Gao, A. (2015). Exploring the Effects of Different Types of Surfactants on Zebrafish Embryos and Larvae. Nature Publishing Group, 1–10. https://doi.org/10.1038/srep10107
Wastiti, T. W., Muryani, S., & Werdiningsih, I. (2017). Pemanfaatan ekstrak bawang putih (Allium sativum L.) Sebagai disinfektan untuk menurunkan angka kuman dinding di ruang laboratorium. Sanitasi: Jurnal Kesehatan Lingkungan, 8(4), 175. https://doi.org/10.29238/sanitasi.v8i4.67
Widyastuti, A., N. (2019). Uji aktivitas antibakteri berbagai konsentrasi ekstrak etanol daun kersen (Muntingia calabura L.) Terhadap pertumbuhan bakteri Klebsiella pneumoniae SECARA IN VITRO. Politeknik Kesehatan Kemenkes Denpasar.
Yuan, C. L., Xu, Z. Z., Fan, M. X., Liu, H. Y., Xie, Y. H., & Zhu, T. (2014). Study on characteristics and harm of surfactants. 6(7), 2233–2237.
Yulianti, I., Elies, M., dan Faisal, I. (2018). Hubungan Perilaku Sedentari Dengan Kejadian Obesitas Pada Remaja Di Smp Negeri 1 Mojoanyar Mojokerto Indra. Jurnal Surya, 10(1), 1–5.
Zheng, Minyi. Lingyun Mo, Ruqiong Qin, Liying Liang and Fan Zhang (2017). Research Progress of Surfactant. AIP Conference Proceedings. AIP Publishing 1794, 030008. https://doi.org/10.1063/1.4971930
Published
2024-02-29
How to Cite
HANIZAR, Evi; ROZZA, Monica Ardilla; MAHARANI, Lila.
Effect Of Antiseptic on Male Mice (Mus musculus L.) Body Weight.
BIOEDUKASI, [S.l.], p. 45-50, feb. 2024.
ISSN 2580-0094.
Available at: <https://jurnal.unej.ac.id/index.php/BIOED/article/view/41070>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.19184/bioedu.v22i1.41070.
Issue
Section
Articles
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
https://orcid.org/0000-0003-1920-0515
