THE IMMUNOGLOBULIN (IgG) ANALYSIS OF IMPLANTATION MICE (Mus musculus L.) POST OVARIECTOMY AFTER TREATMENT OF BLACK SOYBEAN FLOUR EXTRACT (Glycine soja)

  • Yenny Febriana Ramadhan Abdi University of Jember
  • Mahriani Mahriani University of Jember
  • Kartika Senjarini University of Jember
  • Rike Oktarianti Jember univertity

Abstract

Black soybean is one type of plant that has estrogenic activity, it can act as a source of natural exogenous estrogen. Decreased estrogen hormone in the body due to ovariectomy and menopause, it  affect on immune response (IgG). The purpose of this study was to determine the effect of black soybean  extract on immune response (IgG) of implantation mice post ovariectomy. Twenty eight mice were grouped into 4 groups, group 1 (negative control), group 2 (positive control with the administration estradiol concentration 50 ppm), group 3 and 4 were treatment group with the administration of black soybean flour extract doses of 0.31 g/ml and 0.63 g/ml. The data were analyzed using One Way Anova and Duncan Multiple Range Test (DMRT) (p<0,05). The treatment with administration of black soybean flour extract for 10 days in implantation mice post ovariectomy showed that a dose of 0.31 g/ml and dose of 0.63 g/ml had an effect on increasing significantly the  immune response (IgG), i.e 0,12987and 0,12996 respectively.

References

Alagwu, E. A., dan R. O. Nneli. 2005. Effect Of Ovariectomy On The Levels Of Plasma Sex Hormones In Albino Rats. Nigerian Journal Of Physiological Sciences. 20 (1-2): 90-94.

Badziad, A. 2003. Menopause, Danropause, dan TSH. Jakarta: Yayasan Bina Pustaka.

Beshay, E.V. dan B.R. Carr. 2013. Hypothalamic-Pituitary-Ovarian Axis and Control of the Menstrual Cycle. Clinical Reproductive Medicine and Surgery: A Practical Guide: 31-42.

Bouman, A, M.J. Heineman, M.M. Faas. 2005. Sex Hormones and The Immune Response in Humans. Hum Reprod Update. 11: 411-23.

Cutolo M, A. Sulli, S. Capellino, B. Villaggio, P. Montagna, B. Seriolo B dan R.H. Straub. 2004. Sex Hormones Influence on the Immune System: Basic and Clinical Aspects in Autoimmunity. Lupus. 13(9):8-635.

Engdahl, C., A. Bondt, U. Harre, J. Raufer, R. Pfeifle, A. Componeschi, M. Wuhrer, M. Seeling, I. Martensson, F. Nimmerjahn, G. Kronke, H.U. Scherer, H. Forsblad-d’Elia dan G. Schett. 2018. Estrogen Induces St6gal1 Expression and Increases IgG Sialylation in mice and Patients with Rheumatoid Arthritis: a Potential Explanation for the Increased Risk of Rheumatoid Arthritis in Postmenopausal Women. Arthritis Research and Therapy. 20(84): 2-11.


Guo, T.L, K.L. White Jr, R.D. Brown, K.B. Delclos, R.R. Newbold, C. Weis,

Grimaldi, C.M., J. Cleary, A.S. Dagtas, D. Moussai dan B. Diamond. 2002. Estrogen Alters Thresholds for B Cell Apoptosis and Activation. J. Clin Invest. 109:33-1625.

Ortona, E., F. Delunardo, A Maselli, M. Piedorminici, dan W. Malorni. 2015. Sex Hormones and Gender Disparity in Immunity dan Autoimmunity. Ital J Gender-Specific Med. 1(2): 45-50.

Shalaby, A. dan R.A.A. Elgawish. 2015. Influence of Dietary Soy Phytoestrogens on Cytokine Production and Immunoglobulin in Ovariectomized Rats. Int’l Journal of Advances in Chemical Engg. And Biological Sciences. 2(2): 91-95.

Singh, M., P. Chaudhry dan E. Asselin. 2011. Bridging Endometrial Receptivity and Implantation: Network of Hormones, Cytokines, and Growth Factors. Journal of Endocrinology. 210 : 5–14.

Sumalatha, R. Bhat, S.R. Ballal dan S. Acharya. 2012. Studies on Immunomodulatory Effects of Salacia chinensis L. on Albino Rats. Journal of Applied Pharmaceutical Science. 2(9): 98-107.

Tanu, I. 2005.Farmakologi dan Terapi. Ed ke-4. Jakarta: Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia.
Published
2021-04-30
How to Cite
ABDI, Yenny Febriana Ramadhan et al. THE IMMUNOGLOBULIN (IgG) ANALYSIS OF IMPLANTATION MICE (Mus musculus L.) POST OVARIECTOMY AFTER TREATMENT OF BLACK SOYBEAN FLOUR EXTRACT (Glycine soja). BIOEDUKASI: Jurnal Biologi dan Pembelajarannya, [S.l.], v. 19, n. 1, p. 24-29, apr. 2021. ISSN 2580-0094. Available at: <https://jurnal.unej.ac.id/index.php/BIOED/article/view/21099>. Date accessed: 19 june 2021. doi: https://doi.org/10.19184/bioedu.v19i1.21099.
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